Distinct actions of ancestral vinclozolin and juvenile stress on neural gene expression in the male rat

Frontiers in Genetics
Ross GilletteDavid Crews

Abstract

Exposure to the endocrine disrupting chemical vinclozolin during gestation of an F0 generation and/or chronic restraint stress during adolescence of the F3 descendants affects behavior, physiology, and gene expression in the brain. Genes related to the networks of growth factors, signaling peptides, and receptors, steroid hormone receptors and enzymes, and epigenetic related factors were measured using quantitative polymerase chain reaction via Taqman low density arrays targeting 48 genes in the central amygdaloid nucleus, medial amygdaloid nucleus, medial preoptic area (mPOA), lateral hypothalamus (LH), and the ventromedial nucleus of the hypothalamus. We found that growth factors are particularly vulnerable to ancestral exposure in the central and medial amygdala; restraint stress during adolescence affected neural growth factors in the medial amygdala. Signaling peptides were affected by both ancestral exposure and stress during adolescence primarily in hypothalamic nuclei. Steroid hormone receptors and enzymes were strongly affected by restraint stress in the mPOA. Epigenetic related genes were affected by stress in the ventromedial nucleus and by both ancestral exposure and stress during adolescence independently in the ce...Continue Reading

References

Sep 1, 1975·Physiology & Behavior·L D Lytle, B A Campbell
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A YamashitaO Hayaishi
Nov 25, 1993·Nature·E LiR Jaenisch
Mar 10, 1998·Cell·J S Flier, E Maratos-Flier
Oct 17, 1998·Molecular and Cellular Biology·B Hendrich, A Bird
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·N EguchiO Hayaishi
Apr 15, 1999·Annual Review of Neuroscience·A K McAllisterD C Lo
Jan 8, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C M Padovan, F S Guimarães
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·J J HwaE M Parker
Jan 22, 2003·Neuroscience·U UeberhamT Arendt
Jan 24, 2003·The Journal of Comparative Neurology·Toshiro KishiJoel K Elmquist
Jul 5, 2003·Physiological Reviews·P SahJ Power
Apr 29, 2004·Behavioral Neuroscience·Chun-I LiLorey K Takahashi
Jun 5, 2004·Physiology & Behavior·Shannon M Harding, Marilyn Y McGinnis
Jun 17, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Retha R NewboldWendy N Jefferson
Jul 11, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·B SinghR Grantyn
Jul 14, 2006·Journal of Andrology·Matthew D AnwayMichael K Skinner
Sep 16, 2006·Endocrinology·Matthew D AnwayMichael K Skinner
Mar 16, 2007·Neuron·Courtney A Miller, J David Sweatt
Mar 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
Feb 23, 2010·Developmental Psychobiology·Russell D Romeo
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·María A Davis-López de CarrizosaAngel M Pastor
Jul 17, 2010·Hormones and Behavior·David Crews
Feb 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan ZhangHeike Münzberg
Jan 10, 2012·Evolution; International Journal of Organic Evolution·Matthew V Rockman
Mar 17, 2012·International Journal of Epidemiology·Christopher Kuzawa
May 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·David CrewsMichael K Skinner
Sep 20, 2012·F1000 Biology Reports·David Crews, Andrea C Gore
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Faraz A SultanJ David Sweatt
Aug 28, 2013·Molecular and Cellular Biology·Liqing WangWayne W Hancock

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Citations

Nov 18, 2018·Epigenetics : Official Journal of the DNA Methylation Society·Ross GilletteDavid Crews
Dec 9, 2020·Nature Reviews. Endocrinology·David Lopez-RodriguezAnne-Simone Parent

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Methods Mentioned

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