Distinct actions of insulin-like growth factors (IGFs) on placental development and fetal growth: lessons from mice and guinea pigs

Placenta
C T RobertsA N Sferruzzi-Perri

Abstract

Placental insufficiency is thought to be a key factor in many cases of intrauterine growth restriction which complicates about 6% of pregnancies in western countries. Understanding the molecular control of placental and fetal growth is essential to identifying diagnostic and therapeutic targets to improve pregnancy success. Insulin-like growth factor (IGF)-I and IGF-II gene ablation or maternal food restriction reduce tissue and circulating IGF abundance in the fetus, placenta and mother and are associated with both placental and fetal growth restriction. Conversely, in vivo treatment of the pregnant guinea pig with IGF-I or IGF-II from early to mid pregnancy increases fetal weight and enhances placental transport near term. IGF-II, and an IGF2R specific analogue, enhanced placental structural differentiation, whereas IGF-I altered maternal body composition. These outcomes demonstrate endocrine roles within the mother for both IGFs, as well as autocrine/paracrine effects of IGF-II in enhancing placentation and pregnancy success. Therefore, factors that alter placental expression of IGF-II, or maternal circulating IGF-I or IGF-II in early pregnancy may affect placental exchange function late in gestation when the demands of the ...Continue Reading

References

Jul 1, 1987·British Journal of Obstetrics and Gynaecology·T Y KhongW B Robertson
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·A MorrioneR Baserga
Mar 27, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·A SohlströmP C Owens
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·C P SibleyM Constância
Sep 25, 2004·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Adrian R HeardKevin R Priest
Oct 28, 2004·Thrombosis Research·Neil M GudeRoger G King
Jun 7, 2005·Cytokine & Growth Factor Reviews·Adam DenleyBriony E Forbes
Dec 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Miguel ConstânciaAbigail Fowden
Mar 25, 2006·Endocrinology·Amanda N Sferruzzi-PerriClaire T Roberts
Oct 26, 2006·American Journal of Physiology. Endocrinology and Metabolism·Amanda N Sferruzzi-PerriClaire T Roberts
Jan 2, 2007·Placenta·A M Carter

❮ Previous
Next ❯

Citations

Nov 21, 2008·Journal of Mammary Gland Biology and Neoplasia·Anne M RowzeeTeresa L Wood
Jun 11, 2010·Endocrinology·S M Khorshed AlamMichael J Soares
Mar 16, 2011·The Journal of Reproduction and Development·Paul Anthony DawsonDaniel Markovich
Oct 12, 2010·Reproductive Toxicology·Jesús Corría OsorioLoida Sanfiel
Oct 6, 2010·The Journal of Physiology·A N Sferruzzi-PerriC T Roberts
May 3, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Christopher FaulkDana C Dolinoy
Aug 15, 2014·Biology of Reproduction·Paula DíazThomas Jansson
Mar 25, 2018·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Cédric GaleraUNKNOWN EDEN Mother-Child Cohort Study Group
May 21, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·E M BeckettV Padmanabhan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.