Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

Frontiers in Pharmacology
Linlin ZhangRu-Rong Ji

Abstract

Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammatory and neuropathic pain. In this study, we examined the analgesic impact of DHA and DHA-derived SPMs in a mouse model of post-operative pain induced by tibial bone fracture (fPOP). Intravenous perioperative treatment with DHA (500 μg), resolvin D1 (RvD1, 500 ng) and maresin 1 (MaR1, 500 ng), 10 min and 24 h after the surgery, delayed the development of fPOP (mechanical allodynia and cold allodynia). In contrast, post-operative intrathecal (IT) administration of DHA (500 μg) 2 weeks after the surgery had no effects on established mechanical and cold allodynia. However, by direct comparison, IT post-operative treatment (500 ng) with neuroprotectin D1 (NPD1), MaR1, and D-resolvins, RvD1 and RvD5, but not RvD3 and RvD4, effectively reduced mechanical and cold allodynia. ELISA analysis showed that perioperative DHA treatment increased RvD1 levels in serum and spinal cord samples after bone fracture. Interestingly, sham surgery resulted in transient allodynia and increased RvD1 level...Continue Reading

References

Oct 17, 1980·European Journal of Pharmacology·J L Hylden, G L Wilcox
Mar 1, 1996·Pain·T J BrennanG F Gebhart
Jun 17, 1999·Lancet·C J Woolf, R J Mannion
Nov 19, 2003·Archives of Neurology·Robert H DworkinSharon M Weinstein
May 16, 2006·Lancet·Henrik KehletClifford J Woolf
Oct 4, 2006·Neuron·James N Campbell, Richard A Meyer
Jan 24, 2007·The Journal of Experimental Medicine·Camilla I SvenssonCharles N Serhan
Apr 26, 2008·Nature Reviews. Immunology·Charles N SerhanThomas E Van Dyke
Oct 21, 2009·Neuron·Stephen B McMahon, Marzia Malcangio
Oct 16, 2010·Nature Medicine·Michael S Gold, Gerald F Gebhart
Nov 6, 2010·Archives of Pharmacal Research·Sangsu BangSun Wook Hwang
Apr 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucy V NorlingCharles N Serhan
Oct 4, 2011·Trends in Neurosciences·Ru-Rong JiCharles N Serhan
Oct 18, 2011·F1000 Medicine Reports·Claudia Sommer, Frank Birklein
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chul-Kyu ParkRu-Rong Ji
Dec 23, 2011·Annals of Neurology·Niccolò TerrandoMervyn Maze
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charles N SerhanNicos A Petasis
Aug 11, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Zhen-Zhong XuRu-Rong Ji
Feb 27, 2013·Chemistry & Biology·Jesmond DalliCharles N Serhan
May 28, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Niccolò TerrandoLars I Eriksson
Jun 25, 2013·Pain·Ru-Rong JiMaiken Nedergaard
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Meijuan ZhangFeng Zhang
Feb 26, 2014·The Open Pain Journal·Jeffrey Chi-Fei WangGary R Strichartz
May 6, 2014·The Journal of Pain : Official Journal of the American Pain Society·Hanneke L D M WillemenAnnemieke Kavelaars
Feb 11, 2015·The Journal of Clinical Investigation·Giovanna LeoniAsma Nusrat
Sep 18, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhuo-Hao LiuAdina T Michael-Titus
Jan 9, 2016·Scientific Reports·Jeremy W WinklerCharles N Serhan
Jan 21, 2016·Journal of Neuroinflammation·Tzuping WeiJohn David Clark
Feb 10, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Paul C NorrisCharles N Serhan
Apr 10, 2016·Journal of Neuroinflammation·Alessandra Cadete MartiniGiles Alexander Rae
Aug 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hildur H ArnardottirCharles N Serhan

❮ Previous
Next ❯

Citations

Apr 7, 2020·The Journal of Clinical Investigation·Thomas BuchheitRu-Rong Ji
Aug 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rong HuangGurpreet S Baht
May 28, 2020·Frontiers in Pharmacology·Chunrong LiKangding Liu
Nov 19, 2018·Journal of Anesthesia·Megumi MatsudaRu-Rong Ji
Nov 13, 2019·Expert Opinion on Therapeutic Targets·Pei ShangJiachun Feng
Jul 23, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Xueshu TaoRu-Rong Ji
May 10, 2020·Journal of Dental Research·C W WangW V Giannobile
Nov 27, 2019·International Journal of Molecular Sciences·Sung-Min HwangChul-Kyu Park
May 1, 2019·Nutrients·Raquel D S Freitas, Maria M Campos
Jul 23, 2020·Pain·Anthony F DomenichielloChristopher E Ramsden
Mar 10, 2021·Organic & Biomolecular Chemistry·Jannicke Irina NesmanTrond Vidar Hansen
Mar 12, 2021·Cellular and Molecular Neurobiology·Ying LuYong-Jing Gao
Apr 5, 2021·The Journal of Pain : Official Journal of the American Pain Society·Megan L FalsettaDavid C Foster
May 14, 2021·Pain Reports·Terese GeraghtyAnne-Marie Malfait
May 25, 2021·Journal of Leukocyte Biology·Wenzhe WangBei Li
Apr 26, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·Matthew C MauckSamuel A McLean
Jul 29, 2021·Nature Communications·Kaiyuan WangRu-Rong Ji
Sep 4, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Dongdong YaoYonggang Lv
Aug 31, 2021·Frontiers in Pharmacology·Alessandro LeutiMauro Maccarrone

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
Protein Assay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Daisuke AkagiMichael S Conte
The Journal of Immunology : Official Journal of the American Association of Immunologists
Hildur H ArnardottirCharles N Serhan
© 2022 Meta ULC. All rights reserved