Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.

Immunity
GuanQun Liu, Michaela U Gack

Abstract

Faithful maintenance of immune homeostasis relies on the capacity of the cellular immune surveillance machinery to recognize "nonself", such as the presence of pathogenic RNA. Several families of pattern-recognition receptors exist that detect immunostimulatory RNA and then induce cytokine-mediated antiviral and proinflammatory responses. Here, we review the distinct features of bona fide RNA sensors, Toll-like receptors and retinoic-acid inducible gene-I (RIG-I)-like receptors in particular, with a focus on their functional specificity imposed by cell-type-dependent expression, subcellular localization, and ligand preference. Furthermore, we highlight recent advances on the roles of nucleotide-binding oligomerization domain (NOD)-like receptors and DEAD-box or DEAH-box RNA helicases in an orchestrated RNA-sensing network and also discuss the relevance of RNA sensor polymorphisms in human disease.

References

Jan 20, 2004·The Journal of Biological Chemistry·Katalin KarikóDrew Weissman
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Mar 23, 2004·Proceedings of the National Academy of Sciences of the United States of America·Jennifer M LundRichard A Flavell
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katalin KarikóDrew Weissman
Oct 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kenya HondaTadatsugu Taniguchi
Nov 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·J AndrejevaR E Randall
Jan 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith B GordenJohn P Vasilakos
Feb 16, 2005·Nature·Oliver SchulzCaetano Reis e Sousa
Jun 18, 2005·Science·Jungwoo ChoeIan A Wilson
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Simon RothenfusserKatherine A Fitzgerald
Mar 15, 2006·The Journal of Biological Chemistry·Jingchuan SunCheng Kao
Oct 6, 2006·Journal of Virology·Akihiko Komuro, Curt M Horvath
Oct 14, 2006·Science·Andreas PichlmairCaetano Reis e Sousa
Oct 14, 2006·Science·Veit HornungGunther Hartmann
Dec 28, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takeshi SaitoMichael Gale
Feb 3, 2007·Science·Heung Kyu LeeAkiko Iwasaki
Apr 17, 2007·The Journal of Biological Chemistry·C T Ranjith-KumarC Cheng Kao
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thiagarajan VenkataramanGlen N Barber
Jul 27, 2007·Nature·Krishnamurthy MalathiRobert H Silverman
Sep 18, 2007·Science·Shen-Ying ZhangJean-Laurent Casanova
Oct 19, 2007·Journal of Virology·Yueh-Ming LooMichael Gale
Oct 31, 2007·Immunity·Thirumala-Devi KannegantiGabriel Núñez
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joshua N LeonardDavid M Segal
Jan 18, 2008·Nature·Chris B MooreJenny P-Y Ting
Mar 18, 2008·Immunity·Jenny P-Y TingPeter A Ward
Mar 28, 2008·Nature·Mark E KleinmanJayakrishna Ambati
Apr 16, 2008·The Journal of Biological Chemistry·Ayaluru MuraliC Cheng Kao
Apr 29, 2008·Immunity·Marie-Cécile MichalletJürg Tschopp

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Citations

Dec 4, 2020·Journal of Clinical Medicine·Jiri Gallo
Dec 29, 2020·Frontiers in Immunology·Emily Yang, Melody M H Li
Mar 9, 2021·Expert Opinion on Drug Discovery·Xuan HuangMengji Lu
Mar 17, 2021·Trends in Molecular Medicine·Sandra G Williams, Sandra L Wolin
May 4, 2021·Frontiers in Molecular Biosciences·Adrian Gabriel Torres, Eulàlia Martí
May 7, 2021·Experimental & Molecular Medicine·You-Me Kim, Eui-Cheol Shin
Aug 5, 2021·Signal Transduction and Targeted Therapy·Danyang Li, Minghua Wu
Aug 10, 2021·Frontiers in Immunology·Manasa SureshStephan Menne
Aug 21, 2021·Journal of Zhejiang University. Science. B·Yujuan ChenHuashan Yi
Oct 30, 2021·Cellular and Molecular Life Sciences : CMLS·Chunmei CaiChunfu Zheng
Nov 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alisha ChitrakarAlexei Korennykh

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