Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer

Oncotarget
Junyan TaoXin Chen

Abstract

Deregulation of microRNAs (miRNAs) is a typical feature of human hepatocellular carcinoma (HCC). However, the in vivo relevance of miRNAs along hepatocarcinogenesis remains largely unknown. Here, we show that liver tumors induced in mice by c-Myc overexpression or AKT/Ras co-expression exhibit distinct miRNA expression profiles. Among the downregulated miRNAs, eight (miR-101, miR-107, miR-122, miR-29, miR-365, miR-375, miR-378, and miR-802) were selected and their tumor suppressor activity was determined by overexpressing each of them together with c-Myc or AKT/Ras oncogenes in mouse livers via hydrodynamic transfection. The tumor suppressor activity of these microRNAs was extremely heterogeneous in c-Myc and AKT/Ras mice: while miR-378 had no tumor suppressor activity, miR-107, mir-122, miR-29, miR-365 and miR-802 exhibited weak to moderate tumor suppressor potential. Noticeably, miR-375 showed limited antineoplastic activity against c-Myc driven tumorigenesis, whereas it strongly inhibited AKT/Ras induced hepatocarcinogenesis. Furthermore, miR-101 significantly suppressed both c-Myc and AKT/Ras liver tumor development. Altogether, the present data demonstrate that different oncogenes induce distinct miRNA patterns, whose modu...Continue Reading

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Citations

Feb 26, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lei LiXin Chen
May 5, 2016·Biomedit︠s︡inskai︠a︡ khimii︠a︡·A V SmirnovaA N Orekhov
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Sep 6, 2018·Molecular Carcinogenesis·Ze-Bin JiangHui-Ting Yan
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Dec 2, 2020·Journal of Experimental & Clinical Cancer Research : CR·Yuanzhuo GuJunfang Ji
Feb 6, 2021·International Journal of Molecular Sciences·Raphael MohrChristoph Roderburg
Jul 23, 2020·Nature Metabolism·Andrés Méndez-LucasMariia Yuneva
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fang-Ni ChaiXiao-Li Ye
Oct 5, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ningning LiuGuisheng Song

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BETA
xenograft
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PrismGraph
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