PMID: 6165990Jan 1, 1981Paper

Distinct calcium-independent and calcium-dependent adhesion systems of chicken embryo cells

Proceedings of the National Academy of Sciences of the United States of America
R BrackenburyG M Edelman

Abstract

Three criteria have been used to distinguish among different systems of embryonic cell adhesion: dependence on Ca2+, involvement of particular cell-surface molecules, and binding specificity. The characterization of the adhesion with respect to cell-surface molecules was carried out by using specific antibodies against the neural and liver cell adhesion molecules (N-CAM and L-CAM) and antibodies raised against retinal cells prepared by limited trypsinization in the presence of Ca2+ (called "T/Ca cells"). Aggregation of cells prepared from retina or brain without Ca2+ did not require Ca2+ and was inhibited by anti-(N-CAM) antibodies but not by anti-(L-CAM) or anti-T/Ca cell antibodies. In contrast, cells obtained from the same tissues in the presence of Ca2+ did require Ca2+ to aggregate. This aggregation was inhibited by anti-T/Ca cell antibodies but not by anti-(N-CAM) or anti-(L-CAM) antibodies. Hepatocyte aggregation also required Ca2+ and was inhibited only by anti-(L-CAM) antibodies. These results define three antigenically distinct cell adhesion systems in the embryo and raise the possibility that additional systems will be found. The neural Ca2+-independent system displayed a limited tissue specificity, mediating binding...Continue Reading

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Citations

Jan 1, 1985·Cancer Metastasis Reviews·R Brackenbury
Jul 1, 1993·Clinical & Experimental Metastasis·S M Brady-KalnayR Brackenbury
Jul 1, 1985·Developmental Biology·A K Hall, U Rutishauser
Dec 1, 1985·Developmental Biology·D Gibralter, D C Turner
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Feb 1, 1985·Cell Differentiation·N M Troccoli, R E Hausman
Jan 1, 1983·Pharmacology & Therapeutics·S Massa, H B Bosmann
May 1, 1984·Brain Research·O S JørgensenJ M Matthieu
Dec 6, 1989·Biochimica Et Biophysica Acta·B D Shur
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Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C M ChuongG M Edelman
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·U RutishauserG M Edelman
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·B A CunninghamG M Edelman
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanJ P Thiery
Feb 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·W J GallinB A Cunningham
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S HoffmanG M Edelman
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M GrumetG M Edelman
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M E GreenbergG M Edelman
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Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G M EdelmanW J Gallin
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Mar 29, 1994·Proceedings of the National Academy of Sciences of the United States of America·V P MauroG M Edelman
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May 1, 1987·The Journal of Cell Biology·J L DubandJ P Thiery
Dec 1, 1988·The Journal of Cell Biology·D R FriedlanderG M Edelman

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