Distinct cell cycle regulation during saprophytic and pathogenic growth in fungal pathogens

Current Genetics
Cong JiangHuiquan Liu

Abstract

In a number of dimorphic and hemibiotrophic pathogens, cell cycle regulation has been shown to be important for morphological changes related to infectious growth or infection-related morphogenesis. However, the role of mitotic CDK kinase Cdc2, the key regulator of cell cycle, in pathogenic growth is not clear, because most fungal pathogens have a single CDC2 gene that is essential for cell cycle progression and viability. Interestingly, the wheat scab fungus Fusarium graminearum has two CDC2 genes. Although CDC2A and CDC2B have redundant functions in vegetative growth and asexual production, only CDC2A is required for invasive growth and plant infection. In this study, we showed that Cdc2A and Cdc2B interacted with each other and may form homo- and heterodimers in vegetative hyphae. We also identified sequence and structural differences between Cdc2A and Cdc2B that may be related to their functional divergence. These results, together with earlier studies with cyclins, important for differentiation and infection in Candida albicans and Ustilago maydis, indicated that dimorphic and hemibiotrophic fungal pathogens may have stage-specific cyclin-CDK combinations or CDK targets during saprophytic and pathogenic growth.

References

Jan 1, 1997·Annual Review of Cell and Developmental Biology·D O Morgan
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·M D Mendenhall, A E Hodge
Dec 18, 2003·Journal of Cell Science·Tatiana García-MuseJosé Perez-Martín
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Katherine A BorkovichRobert Pratt
Nov 1, 2005·The Plant Cell·Sonia Castillo-Lluva, José Pérez-Martín
Aug 10, 2006·Molecular Genetics and Genomics : MGG·José Pérez-MartínNatalia Carbó
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Joanna Bloom, Frederick R Cross
Aug 21, 2007·Current Opinion in Microbiology·Zaira Caracuel-Rios, Nicholas J Talbot
Oct 20, 2009·Current Opinion in Microbiology·Yue Wang
Oct 29, 2009·Journal of Cell Science·Natalia MielnichukJosé Pérez-Martín
Dec 22, 2009·Eukaryotic Cell·Duncan Wilson, Bernhard Hube
Mar 2, 2010·The Plant Cell·Diane G O SaundersNicholas J Talbot
May 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sébastien DuplessisFrancis Martin
Jan 5, 2012·PLoS Pathogens·Chenfang WangJin-Rong Xu
Apr 10, 2013·Trends in Cell Biology·Hirofumi HarashimaArp Schnittger
Aug 21, 2013·Current Genetics·R Teparić, Vladimir Mrsa
Sep 24, 2013·Current Genetics·Ivan HapalaLubomír Tomáška
Oct 24, 2013·Nature Communications·Wenming ZhengZhensheng Kang
Jul 18, 2015·Cell·Erdem SendincYang Shi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.