Distinct cerebellar engrams in short-term and long-term motor learning

Proceedings of the National Academy of Sciences of the United States of America
Wen WangRyuichi Shigemoto

Abstract

Cerebellar motor learning is suggested to be caused by long-term plasticity of excitatory parallel fiber-Purkinje cell (PF-PC) synapses associated with changes in the number of synaptic AMPA-type glutamate receptors (AMPARs). However, whether the AMPARs decrease or increase in individual PF-PC synapses occurs in physiological motor learning and accounts for memory that lasts over days remains elusive. We combined quantitative SDS-digested freeze-fracture replica labeling for AMPAR and physical dissector electron microscopy with a simple model of cerebellar motor learning, adaptation of horizontal optokinetic response (HOKR) in mouse. After 1-h training of HOKR, short-term adaptation (STA) was accompanied with transient decrease in AMPARs by 28% in target PF-PC synapses. STA was well correlated with AMPAR decrease in individual animals and both STA and AMPAR decrease recovered to basal levels within 24 h. Surprisingly, long-term adaptation (LTA) after five consecutive daily trainings of 1-h HOKR did not alter the number of AMPARs in PF-PC synapses but caused gradual and persistent synapse elimination by 45%, with corresponding PC spine loss by the fifth training day. Furthermore, recovery of LTA after 2 wk was well correlated wi...Continue Reading

References

Aug 8, 1988·The Journal of Comparative Neurology·R M Napper, R J Harvey
May 1, 1974·The Journal of Comparative Neurology·D M Landis, T S Reese
Jun 26, 2004·Annual Review of Neuroscience·Edward S BoydenJennifer L Raymond
Nov 10, 2005·Proceedings of the National Academy of Sciences of the United States of America·John P WelshRodolfo R Llinás
Jun 2, 2006·The Journal of Comparative Neurology·Martijn SchonewilleChris I De Zeeuw
Feb 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miwako Masugi-TokitaRyuichi Shigemoto
May 15, 2007·Current Opinion in Neurobiology·Miwako Masugi-Tokita, Ryuichi Shigemoto
Aug 28, 2007·Neurobiology of Learning and Memory·Kea Joo LeeIm Joo Rhyu
Oct 5, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Corina E AndreescuMarcel T G De Jeu
Oct 31, 2007·PLoS Computational Biology·John Porrill, Paul Dean
Jul 29, 2009·Behavioral Neuroscience·S ConnorA C W Weeks
Oct 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Etsuko TarusawaRyuichi Shigemoto
Apr 13, 2011·Neuron·Martijn SchonewilleChris I De Zeeuw
Aug 17, 2012·Nature Reviews. Neuroscience·Zhenyu GaoChris I De Zeeuw

❮ Previous
Next ❯

Citations

Feb 15, 2008·Journal of Computational Neuroscience·K J KelleherK Josić
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Wajeeha AzizRyuichi Shigemoto
Jun 30, 2014·The Cerebellum·Tomoo Hirano
Jul 22, 2014·The Journal of Comparative Neurology·María E RubioRyuichi Shigemoto
Mar 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Tadashi YamazakiShigeru Tanaka
Sep 28, 2016·Nature Neuroscience·Claire PiochonChristian Hansel
Feb 18, 2017·Journal of Neurochemistry·Chihiro Hisatsune, Katsuhiko Mikoshiba
Jun 14, 2017·Proceedings of the National Academy of Sciences of the United States of America·Takeyuki SugawaraKatsuhiko Mikoshiba
Jul 10, 2018·Annual Review of Neuroscience·Jennifer L Raymond, Javier F Medina
Nov 13, 2015·Journal of Neurophysiology·Michael A GaffieldJason M Christie
Apr 9, 2020·Frontiers in Cellular Neuroscience·Kohgaku EguchiRyuichi Shigemoto
Jul 28, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Svenja Brodt, Steffen Gais

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.