PMID: 9523578Apr 2, 1998Paper

Distinct changes in peptide YY binding to, and mRNA levels of, Y1 and Y2 receptors in the rat hippocampus associated with kindling epileptogenesis

Journal of Neurochemistry
M GobbiA Vezzani

Abstract

Electrical kindling of the rat dorsal hippocampus induced significant changes in the binding of 125I-peptide YY to Y1 and Y2 subtypes of neuropeptide Y receptors and in their mRNA levels in the area dentata as assessed by quantitative receptor autoradiography and in situ hybridization histochemistry. Binding to Y1 receptor sites decreased by 50% (p < 0.05) in the molecular layer of the stimulated dentate gyrus, 2 days after preconvulsive stage 2 and 1 week or 1 month after generalized stage 5 seizures compared with sham-stimulated rats. Binding to Y2 receptor sites increased bilaterally by 36-87% (p < 0.05) in the hilus at stage 2 and 1 week or 1 month after stage 5. No significant changes were observed after one afterdischarge or in the other hippocampal subfields or in the cortex. Y1 receptor mRNA signal decreased bilaterally by 50-64% (p < 0.01) in the granule cell layer, 6 h but not 24 h after stages 2 and 5. The Y2 receptor mRNA signal was enhanced by 283% (p < 0.01) in the stimulated granule cell layer 24 h after stage 2. At 6 and 24 h after stage 5, mRNA levels were increased both ipsilaterally (283 and 360%, respectively; p < 0.01) and contralaterally (190 and 260%, respectively; p < 0.05). No significant changes in lev...Continue Reading

Citations

Aug 19, 2007·Epilepsy Currents·Andre H Lagrange
Apr 8, 2014·Molecular Neurobiology·Elke ClynenJean-Michel Rigo
Aug 20, 2003·The European Journal of Neuroscience·Ramla BenmaamarAntoine Depaulis
Dec 17, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alberto BacciDavid A Prince
Aug 19, 2003·Hippocampus·Sophie ReibelAntoine Depaulis
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·A NanobashviliZ Kokaia
Sep 30, 2005·The European Journal of Neuroscience·Bouchaïb El BahhWilliam F Colmers
Jan 1, 2010·Hippocampus·Marco LedriMerab Kokaia
Mar 23, 2012·Journal of Neuropathology and Experimental Neurology·Meinrad DrexelGünther Sperk
Dec 15, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana P SilvaJoão O Malva
Feb 4, 2005·The Journal of Comparative Neurology·Toshiro KishiJoel K Elmquist
Sep 23, 2006·Frontiers in Neuroendocrinology·Carola EvaAlessandra Oberto

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