Distinct characteristics in Japanese dermatitis herpetiformis: a review of all 91 Japanese patients over the last 35 years

Clinical & Developmental Immunology
Chika OhataTakashi Hashimoto

Abstract

We reviewed all 91 Japanese dermatitis herpetiformis (DH) patients reported over the last 35 years. The male-to-female ratio was 2 : 1. The mean age at onset was 43.8, and 13 years earlier for female patients. More than half of these Japanese DH patients showed granular IgA deposition in the papillary dermis, and another one-third showed fibrillar IgA deposition. The male patients with granular IgA deposition were 10 years older than those with fibrillar deposition. Whereas patients with granular IgA deposition showed typical distribution of the skin lesions, the predilection sites of DH tended to be spared in patients with fibrillar IgA deposition. Only 3 patients had definite gluten-sensitive enteropathy. There was a statistical difference in the frequency of human leukocyte antigen (HLA)-DR9 between the granular group and controls among Japanese. No patients had HLA-DQ2 or -DQ8, which is frequently found in Caucasian DH patients. The absence of HLA-DQ2/DQ8, the inability to identify celiac disease in most cases, the predominance of fibrillar IgA, and the unusual distribution of clinical lesions in Japanese patients suggest that Japanese DH may be a subset of DH patients and have a pathogenesis which is different from that cu...Continue Reading

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Citations

Mar 12, 2016·The Journal of Investigative Dermatology·Yonghu SunFuren Zhang
Jun 30, 2015·The British Journal of Dermatology·C OhataT Hashimoto
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Feb 18, 2017·American Journal of Clinical Dermatology·Ziyou RenJonathan I Silverberg
Jun 12, 2021·Indian Journal of Dermatology, Venereology and Leprology·Raghavendra RaoVarsha M Shetty
Aug 28, 2021·Medicina·Christopher N Nguyen, Soo-Jung Kim
Apr 26, 2019·Case Reports in Nephrology and Dialysis·Yoshio ShimizuYusuke Suzuki

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Methods Mentioned

BETA
electron microscopy
biopsy
biopsies
ELISA
genotyping

Software Mentioned

Ichushi Web
SPSS

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