Distinct chemokinetic and chemotactic responses in neutrophil granulocytes

European Journal of Immunology
H U KellerH Cottier

Abstract

Evidence has been presented to show that chemokinesis and chemotaxis of human neutrophil granulocytes can be controlled by distinct cellular mechanisms and by different chemicals. Materials such as human serum albumin or fibrinogen had chemokinetic but no chemotactic properties. Highly purified preparations of serum-derived peptides containing classical anaphylatoxin had detectable chemotactic activity only. Chemokinetic as well as chemotactic substances were required for the expression of chemotaxis in the form of efficient directional locomotion. The roles of chemokinesis and chemotaxis in the regulation of directional locomotion have been analyzed. Further experiments showed that the chemotactic response conforms to the law of Weber-Fechner. The number of cells which had accumulated in response to a chemotactic simulus was proportional to the logarithm of the concentration of the chemical substance. Readaptation from high to low chemotactic stimulus occurred only to a limited extent.

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Citations

Jan 1, 1980·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·F PatroneC Sacchetti
Oct 15, 1977·Experientia·H U KellerH Cottier
Jan 1, 1979·Folia Microbiologica·I MilerL Hromádková
Feb 6, 2008·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Erinn S RabornGuy A Cabral
Mar 1, 1983·Veterinary Immunology and Immunopathology·G S Smith, J H Lumsden
Jan 21, 2009·Expert Reviews in Molecular Medicine·Guy A Cabral, LaToya Griffin-Thomas
Dec 15, 1979·Experientia·H U KellerJ Ploem
Aug 1, 1985·Pathology, Research and Practice·H Keller, H Cottier
Nov 27, 2007·British Journal of Pharmacology·G A CabralF Marciano-Cabral
Nov 4, 2016·Scientific Reports·Honda NaokiShin Ishii
Aug 1, 1979·Journal of the Royal Society of Medicine·P C Wilkinson
Jun 1, 1986·Biochemical Medicine and Metabolic Biology·M SolymossyF Antoni
Dec 7, 1979·Journal of Theoretical Biology·D Lauffenburger, K H Keller
Aug 10, 2021·Frontiers in Immunology·Kylie B R BelchamberElizabeth Sapey

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