PMID: 6166965Feb 1, 1981Paper

Distinct classes of substance P receptors revealed by a comparison of the activities of substance P and some of its segments

Regulatory Peptides
V I TeichbergS Blumberg

Abstract

The contracting potency of Substance P and of its C-terminal fragments was studied using four isolated preparations of smooth muscle. The Substance P receptors in the four muscles studied can be differentiated on the basis of their interactions with Substance P and its C-terminal fragments. On the guinea pig ileum, the potency of Substance P is equal to that of the C-terminal octa- and heptapeptide segments and in the rat ileum the potency of Substance P is equal to that of the C-terminal octapeptide and even higher than that of the heptapeptide. In contrast, on the cow pupillary sphincter and guinea pig urinary bladder, Substance P is markedly less potent that the C-terminal octa-, hepta- and hexapeptides. These results suggest the existence of different classes of Substance P receptors and indicate that the N-terminal sequence may be important in regulating Substance P activity.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·M Otsuka, T Takahashi
Sep 12, 1979·Biochemical and Biophysical Research Communications·S Blumberg, V I Teichberg
Jul 1, 1979·Acta Physiologica Scandinavica·A BillG Nilsson
Sep 1, 1977·Clinical and Experimental Pharmacology & Physiology·R W Bury, M L Mashford
Jun 1, 1976·Journal of Medicinal Chemistry·R W Bury, M L Mashford

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Citations

Aug 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·U Holzer-PetscheF Lembeck
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·C M LeeB E Sandberg
Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·G SkofitschF Lembeck
Mar 11, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Petra C ArckRalf Paus
Oct 15, 1982·European Journal of Pharmacology·J W Growcott, A V Tarpey
Jan 28, 1983·European Journal of Pharmacology·S P WatsonL L Iversen
Sep 30, 1983·European Journal of Pharmacology·S P Watson, C P Downes
Oct 14, 1983·European Journal of Pharmacology·H J CheesemanG Henderson
Jan 27, 1984·European Journal of Pharmacology·D RegoliJ Mizrahi
Feb 13, 2001·Journal of Internal Medicine·T HökfeltJ Wahren
Jul 1, 1986·British Journal of Pharmacology·E E DanielK H Robotham
Nov 1, 1986·International Journal of Peptide and Protein Research·M Cotrait, M Hospital
Jan 2, 1984·Klinische Wochenschrift·E Heymann, R Mentlein

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