Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline

Journal of Alzheimer's Disease : JAD
Gonzalo Sánchez-BenavidesJose Luis Molinuevo

Abstract

Subtle cognitive decline preceding cognitive impairment can be self-perceived, referred to as subjective cognitive decline (SCD), or go unrecognized. To study the clinical, cognitive, and structural neuroimaging characteristics of psychometrically normal subjects without self-awareness of cognitive decline (unaware decliners, UD) and to compare them with SCD participants and controls. 2,640 participants from the ALFA cohort, 1,899 controls, 173 UD (decline reported by the informant only), and 568 SCD underwent clinical and cognitive explorations. A subset of 530 underwent structural MRI (379 Controls; 43 UD; 108 SCD). Linear models adjusting for confounders (age, sex, education, and mood state) were used to assess group differences on cognition and voxel-wise grey matter (GM) volumes. 6.6% were UD while 21.5% SCD. No differences in anxiety and depression were observed between controls and UD, while SCD did (p < 0.01). UD showed lower performance in the Memory Binding Test free recall (p < 0.005) than controls, but no differences compared to SCD. Right medial frontal and insular increments of GM volumes were observed in UD with respect to controls. Informant report of decline in UD and SCD was associated with lower left hippocam...Continue Reading

References

Oct 8, 1988·BMJ : British Medical Journal·D GoldbergD Grayson
Jan 30, 2004·Psychosomatic Medicine·Harald GündelJesús Pujol
Sep 19, 2006·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Esen SakaSevin Balkan
Apr 21, 2007·Journal of the International Neuropsychological Society : JINS·Michele L RiesSterling C Johnson
Jul 22, 2008·International Journal of Geriatric Psychiatry·Inez H G B RamakersFrans R J Verhey
Aug 23, 2008·Journal of Affective Disorders·Genoveffa BorsciGiovanni B Frisoni
Aug 18, 2009·Dementia and Geriatric Cognitive Disorders·J L RobertsR T Woods
May 4, 2010·Psychological Science·Colin G DeYoungJeremy R Gray
Mar 9, 2011·International Journal of Geriatric Psychiatry·Lorena RamiJose Luis Molinuevo
Apr 16, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Melissa J SlavinPerminder S Sachdev
Jun 14, 2012·Journal of the American Geriatrics Society·Laura A RabinRichard B Lipton
Jul 23, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Katherine A GiffordAngela L Jefferson
Mar 15, 2014·Journal of Alzheimer's Disease : JAD·Lorena RamiJose L Molinuevo
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Dec 8, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sergio E Starkstein
Jun 7, 2015·Neuropsychologia·Stephanie CosentinoYaakov Stern
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Nina GramuntJosé L Molinuevo
Mar 26, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bruno DuboisUNKNOWN Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclin
Apr 12, 2016·Journal of Alzheimer's Disease : JAD·Nina GramuntJosé L Molinuevo
Nov 9, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·José L MolinuevoUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Apr 8, 2017·Neuropsychologia·Patrizia VanniniReisa A Sperling
May 10, 2017·Annual Review of Clinical Psychology·Laura A RabinRebecca E Amariglio
Jun 1, 2017·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Marie EckerströmAnders Wallin
Jul 26, 2017·Neuropsychiatric Disease and Treatment·Hiroshi FujimotoJin Narumoto
Mar 3, 2016·Alzheimer's & Dementia : Translational Research & Clinical Interventions·José Luis MolinuevoJordi Camí
Jan 22, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Beth E SnitzMary Ganguli
Feb 16, 2018·Neurology·Joseph TherriaultUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 2, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Raffaele CacciagliaUNKNOWN ALFA study
Apr 15, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Clifford R JackUNKNOWN Contributors

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Citations

Nov 22, 2019·Annals of Neurology·Bernard J HanseeuwUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 22, 2019·Alzheimer Disease and Associated Disorders·M Bailee BoggessAllison Caban-Holt
Oct 16, 2020·Alzheimer's Research & Therapy·Federica CacciamaniUNKNOWN INSIGHT-PreAD study group
Dec 20, 2020·Experimental Gerontology·Lorenzo Pini, Alexandra M Wennberg
Dec 5, 2019·NeuroImage. Clinical·Carlos Muñoz-NeiraCatherine Pennington
Aug 21, 2021·Frontiers in Aging Neuroscience·Federica CacciamaniStéphane Epelbaum

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Clinical Trials Mentioned

NCT01835717

Software Mentioned

SPM
DARTEL
SCD
Statistical Parametrical Mapping SPM

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