Distinct compartmentalization of CD4+ T-cell effector function versus proliferative capacity during pulmonary cryptococcosis

The American Journal of Pathology
Dennis M LindellGary B Huffnagle

Abstract

The activation and expansion of T cells and their acquisition of effector function are key steps in the development of the adaptive immune response. Most infections are predominantly outside of the lymphoid tissues, and it is unclear at what point developmentally and anatomically T cells acquire effector function in vivo. In these studies, we compared the activation and polarization of T cells during murine pulmonary Cryptococcus neoformans infection in the secondary lymphoid tissues and at the site of primary infection. Few CD4(+) and CD8(+) T cells expressed an activated phenotype (CD44(hi,) CD25(+), CD69(+), CD62L(lo), CD45RB(lo)) at the sites of clonal expansion (lymph nodes, spleen, and blood). In contrast, a high percentage of T cells expressed activation markers at the site of primary infection, the lungs. Additionally, the polarization of CD4(+) T cells to interferon-gamma-producing effector cells occurred at the site of infection, the lungs. CD4(+) and CD8(+) T cells from secondary lymphoid organs responded to TCR restimulation by proliferating, whereas T cells from the lungs proliferated poorly. This report demonstrates for the first time that T-cell activation and effector function in secondary lymphoid tissues durin...Continue Reading

References

Apr 1, 1991·The Journal of Experimental Medicine·G B HuffnagleM F Lipscomb
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·T R MalekE M Shevach
Sep 1, 1994·Stem Cells·S F ZieglerM R Alderson
Mar 1, 1996·The Journal of Experimental Medicine·E MurphyA O'Garra
Sep 5, 1998·Immunity·J J BirdS L Reiner
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C PopeL Lefrançois
Apr 17, 2001·The Journal of Experimental Medicine·G IezziA Lanzavecchia
Jun 8, 2001·Trends in Microbiology·M FeldmesserA Casadevall
Oct 3, 2001·The Journal of Experimental Medicine·W WeningerU H von Andrian
Feb 6, 2002·The Journal of Experimental Medicine·Nicola L HarrisGraham Le Gros
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amanda L MarzoLeo Lefrançois
Aug 28, 2003·Nature Immunology·Robert A Seder, Rafi Ahmed
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brandon M SullivanLaurie H Glimcher

❮ Previous
Next ❯

Citations

Jan 31, 2009·Medical Mycology·Luigina Romani
Aug 21, 2010·Future Microbiology·Michal A OlszewskiGary B Huffnagle
Oct 28, 2011·Trends in Immunology·Clare L Bennett, Ronjon Chakraverty
Mar 21, 2007·Immunological Reviews·Denise E KirschnerJennifer J Linderman
Jun 29, 2010·The American Journal of Pathology·Yanmei ZhangMichal A Olszewski
Nov 26, 2015·Future Microbiology·Alison J EastmanMichal A Olszewski
May 3, 2011·PloS One·Steven P TempletonDonald H Beezhold
Feb 23, 2010·PloS One·Neelkamal ChaudharyKieren A Marr
Jan 16, 2018·Journal of Fungi·Liliane Mukaremera, Kirsten Nielsen
Jun 16, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lori M NealMichal A Olszewski
Feb 1, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael J DavisMichal A Olszewski
Jun 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·John J OsterholzerGalen B Toews

❮ Previous
Next ❯

Related Concepts

Related Feeds

Babesiosis

Babesiosis is caused by parasites of the genus babesia, which are transmitted in nature by the bite of an infected tick. Discover the latest research on babesiosis here.