Distinct Contributions of Autophagy Receptors in Measles Virus Replication

Viruses
Denitsa S PetkovaMathias Faure

Abstract

Autophagy is a potent cell autonomous defense mechanism that engages the lysosomal pathway to fight intracellular pathogens. Several autophagy receptors can recognize invading pathogens in order to target them towards autophagy for their degradation after the fusion of pathogen-containing autophagosomes with lysosomes. However, numerous intracellular pathogens can avoid or exploit autophagy, among which is measles virus (MeV). This virus induces a complete autophagy flux, which is required to improve viral replication. We therefore asked how measles virus interferes with autophagy receptors during the course of infection. We report that in addition to NDP52/CALCOCO₂ and OPTINEURIN/OPTN, another autophagy receptor, namely T6BP/TAXIBP1, also regulates the maturation of autophagosomes by promoting their fusion with lysosomes, independently of any infection. Surprisingly, only two of these receptors, NDP52 and T6BP, impacted measles virus replication, although independently, and possibly through physical interaction with MeV proteins. Thus, our results suggest that a restricted set of autophagosomes is selectively exploited by measles virus to replicate in the course of infection.

References

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Citations

Dec 1, 2017·Viruses·Aurore RozièresMathias Faure
Dec 14, 2017·Essays in Biochemistry·David G McEwan
Mar 1, 2018·Frontiers in Microbiology·Yupeng WangChan Ding
Nov 7, 2018·Journal of Cell Science·Pablo Sánchez-Martín, Masaaki Komatsu
Nov 9, 2018·Frontiers in Cellular and Infection Microbiology·Michelle L PleetFatah Kashanchi
Nov 30, 2018·Frontiers in Cell and Developmental Biology·Vartika SharmaDhiraj Kumar
Jan 24, 2020·Frontiers in Microbiology·Shuangqi FanJinding Chen
Aug 30, 2018·Cell Death and Differentiation·Yasir MohamudHonglin Luo
Mar 20, 2020·International Journal of Molecular Sciences·Shuangqi FanJinding Chen
Mar 9, 2021·Trends in Microbiology·Christophe ViretMathias Faure
Jun 26, 2021·Cellular & Molecular Biology Letters·Päivi Ylä-Anttila

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Methods Mentioned

BETA
GTPase
confocal microscopy
transfection
Assay
co-affinity purification
Co-Affinity

Software Mentioned

FlowJo
MeV
ImageJ

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