Distinct contributions of model MaSp1 and MaSp2 like peptides to the mechanical properties of synthetic major ampullate silk fibers as revealed in silico.

Nanotechnology, Science and Applications
Amanda E BrooksRandolph V Lewis

Abstract

All characterized major ampullate silks from orb-web weaving spiders are composites of primarily two different proteins: MaSp1 and MaSp2. The conserved association of MaSp1 and MaSp2 in these spider species, the highly conserved amino acid motifs, and variable ratios of MaSp1 to MaSp2 demonstrate the importance of both MaSp1 and MaSp2 to the strength and elasticity of the fiber. Computer simulated mechanical tests predicted differing roles for MaSp1 and MaSp2 in the mechanical properties of the fibers. Recombinant MaSp1 and MaSp2 proteins were blended and spun into fibers mimicking the computer-simulated conditions. Mechanical testing verified the differing roles of MaSp1 and MaSp2.

Citations

May 26, 2012·Journal of the Royal Society, Interface·Sean J BlamiresI-Min Tso
Sep 13, 2018·Macromolecular Bioscience·James Sparkes, Chris Holland
Apr 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Anna FlorczakHanna Dams-Kozlowska
Oct 25, 2016·International Journal of Molecular Sciences·Christine Radtke
Nov 3, 2010·The Journal of Experimental Biology·S J BlamiresI-M Tso
May 31, 2021·Insect Biochemistry and Molecular Biology·R Crystal ChawCheryl Y Hayashi
Feb 1, 2020·Biomacromolecules·Thomas W DuggerDavid J Kisailus
May 8, 2017·ACS Biomaterials Science & Engineering·Lisa D Muiznieks, Fred W Keeley

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