PMID: 2092293Dec 1, 1990Paper

Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes

Parasitology
S V GrahamJ D Barry

Abstract

The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire. We have developed a model system for the analysis of metacyclic VSG (M-VSG) gene expression and have used this to demonstrate that, for two M-VSG genes, different modes of expression operate in the insect and mammalian phases of the life-cycle. In metacyclic-derived clones, these genes are expressed in situ, whereas they are routinely activated by duplication in bloodstream trypanosomes. The expression loci for both M-VSG genes studied are structurally simple and we present a model, based on this, for the maintenance of a separate M-VSG repertoire and expression system.

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Citations

Jun 1, 1995·Molecular and Biochemical Parasitology·Y L NagoshiJ E Donelson
Jul 1, 1996·Molecular and Biochemical Parasitology·V S Graham, J D Barry
May 9, 1998·Molecular and Biochemical Parasitology·G A CrossM Navarro
May 9, 1998·Molecular and Biochemical Parasitology·J D BarryB Wymer
Jun 1, 1997·Molecular and Biochemical Parasitology·K P DaviesG A Cross
Dec 2, 2010·Microbiology and Molecular Biology Reviews : MMBR·Jan-Peter DanielsBill Wickstead
Apr 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G A Cross
Sep 28, 1998·Biochimica Et Biophysica Acta·L L Vieira
Jun 1, 1995·Parasitology Today·S V Graham
Aug 6, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael B DrennanStefan Magez
Aug 24, 1999·Molecular and Cellular Biology·N P RobinsonJ D Barry
Jun 1, 1995·Microbiological Reviews·L Vanhamme, E Pays
Aug 1, 1994·Molecular and Cellular Biology·C M AlarconJ E Donelson

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