Abstract
Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC). Methods: The biological function of the MCM genes were investigated by bioinformatics analysis. The diagnostic and prognostic values of the MCM genes were investigated by using the data of HCC patients from the GSE14520 and The Cancer Genome Atlas (TCGA) databases. Results: Bioinformatics analysis of the MCM genes substantiated that MCM2-7 genes were significantly enriched in DNA replication and cell cycle, and co-expressed with each other. These genes also co-expressed in HCC tumor tissue in both the GSE14520 and TCGA cohort. We also observed that the expression of the MCM2-7 genes was increased in tumor tissue, and diagnostic receiver operating characteristic analysis of MCM2-7 indicated that these genes could serve as sensitive diagnostic markers in HCC. Survival analysis in the GSE14520 cohort suggested that expression of MCM2, MCM4, MCM5, and MCM6 were significantly associated with hepatitis B virus-related HCC overall survival (OS). However, none of the MCM genes were associated with recurrence-free survival in the GSE14520 cohort. Th...Continue Reading
Citations
Jul 20, 2019·PloS One·Kang LiuRensheng Wang
Dec 7, 2019·Cancer Medicine·Xin ZhouTao Peng
Apr 21, 2020·IUBMB Life·Wen-Yu HuRui Feng
Jul 1, 2020·Bioscience Reports·He ZhouTong Zhou
Jul 24, 2020·JCI Insight·Lindsay T FourmanSteven K Grinspoon
Nov 7, 2019·PeerJ·Jun LiuLirui Tang
Feb 25, 2020·Analytical Cellular Pathology (Amsterdam)·Si YuYang Chen
Jan 31, 2020·Frontiers in Genetics·Harpreet KaurGajendra P S Raghava
Aug 12, 2020·Cancer Medicine·Jianwei LiuRong Li
Nov 13, 2020·Frontiers in Oncology·Longshan ZhangJian Guan
Jan 25, 2021·Pharmacology Research & Perspectives·Nan MeiChunli Li
Oct 30, 2020·Cancer Management and Research·Wei WanQuanxi Li
Feb 20, 2021·Life Sciences·Yu LeiDean Tian
Aug 22, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Yifei WangWei Kang
Jul 2, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sadiya Bi ShaikhYashodhar P Bhandary
Aug 3, 2021·BioMed Research International·Junwei LiuChengwu Zhang
Dec 4, 2021·JCO Clinical Cancer Informatics·Seyedeh Faezeh HassaniZinat Shams