Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Journal of Cancer
Xiwen LiaoTao Peng

Abstract

Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC). Methods: The biological function of the MCM genes were investigated by bioinformatics analysis. The diagnostic and prognostic values of the MCM genes were investigated by using the data of HCC patients from the GSE14520 and The Cancer Genome Atlas (TCGA) databases. Results: Bioinformatics analysis of the MCM genes substantiated that MCM2-7 genes were significantly enriched in DNA replication and cell cycle, and co-expressed with each other. These genes also co-expressed in HCC tumor tissue in both the GSE14520 and TCGA cohort. We also observed that the expression of the MCM2-7 genes was increased in tumor tissue, and diagnostic receiver operating characteristic analysis of MCM2-7 indicated that these genes could serve as sensitive diagnostic markers in HCC. Survival analysis in the GSE14520 cohort suggested that expression of MCM2, MCM4, MCM5, and MCM6 were significantly associated with hepatitis B virus-related HCC overall survival (OS). However, none of the MCM genes were associated with recurrence-free survival in the GSE14520 cohort. Th...Continue Reading

Citations

Jul 24, 2020·JCI Insight·Lindsay T FourmanSteven K Grinspoon
Feb 25, 2020·Analytical Cellular Pathology (Amsterdam)·Si YuYang Chen
Aug 22, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Yifei WangWei Kang

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Datasets Mentioned

BETA
GSE14520

Software Mentioned

SPSS
Search Tool for the
GeneMANIA
R
BiNGO
Biological Networks Gene Ontology tool ( BiNGO )
DAVID
limma
corrplot
survivalROC

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Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.