Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis

FEMS Microbiology Letters
Malgorzata Korycka-MachalaJaroslaw Dziadek

Abstract

Mycobacterium smegmatis was used to study the relationship between DNA repair processes involving RecA and nonhomologous end joining (NHEJ). The effect of gene deletions in recA and/or in two genes involved in NHEJ (ku and ligD) was tested on the ability of bacteria to join breaks in plasmids transformed into them and in their response to chemicals that damage DNA. The results provide in vivo evidence that only NHEJ is required for the repair of noncompatible DNA ends. By contrast, the response of mycobacteria to mitomycin C preferentially involved a RecA-dependent pathway.

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Citations

Oct 17, 2007·Nature Reviews. Microbiology·Stewart Shuman, Michael S Glickman
Jan 22, 2008·The Journal of Biological Chemistry·Hui Zhu, Stewart Shuman
May 10, 2007·Nucleic Acids Research·Hui Zhu, Stewart Shuman
Jun 6, 2007·Antimicrobial Agents and Chemotherapy·Malgorzata Korycka-MachalaJarosław Dziadek
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Jan 30, 2018·Current Medicinal Chemistry·Alina MiniasJarosław Dziadek
Dec 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yunshan WangGuangwei Wei
Sep 2, 2016·Bioscience Reports·Giulia PergolizziRichard Peter Bowater
Dec 14, 2021·Frontiers in Molecular Biosciences·Benhur AmareSara N Andres

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