Abstract
The role of interleukin (IL)-23 in asthma pathophysiology is still controversial. We examined its role in allergic airway inflammation in response to two distinct antigens using IL-23-deficient mice. Allergic airway inflammation was evaluated in wild-type and IL-23p19(-/-) mice. Mice were sensitized to ovalbumin (OVA) or house dust mite (HDM) by intraperitoneal injection of antigen and their airways were then exposed to the same antigen. Levels of antigen-specific immunoglobulins in serum as well as cytokines in bronchoalveolar or peritoneal lavage fluid and lung tissue were determined by enzyme-linked immunosorbent assay and/or quantitative polymerase chain reaction. Deficiency of IL-23p19 decreased eosinophils and Th2 cytokines in bronchoalveolar lavage fluid (BALF) of OVA-treated mice, while it increased BALF eosinophils of HDM-treated mice. Peritoneal injection of OVA with alum, but not of HDM, induced local synthesis of IL-6, IL-10, and IL-23. Systemic production of antigen-specific IgG1 was partially dependent on IL-23. In contrast, airway exposure to HDM, but not to OVA, induced IL-23p19 mRNA expression in the lungs. In IL-23p19-deficient mice, HDM-exposed lungs did not exhibit the induction of IL-17A, which negatively r...Continue Reading
References
Jun 8, 1999·Annual Review of Immunology·M Wills-Karp
Jan 4, 2001·The New England Journal of Medicine·A B Kay
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·S MoletJ Chakir
Oct 2, 2002·Immunity·Susumu NakaeYoichiro Iwakura
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Peter W HellingsJan L Ceuppens
Mar 1, 2003·Nature·Daniel J CuaJonathon D Sedgwick
May 27, 2003·Nature Reviews. Immunology·Christina A Herrick, Kim Bottomly
Mar 23, 2004·Annual Review of Immunology·Lauren CohnGeoffrey L Chupp
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua
Jun 20, 2006·Immunity·Casey T WeaverKenneth M Murphy
Nov 7, 2006·Respiratory Research·Dominique M A BullensJan L Ceuppens
Nov 15, 2006·The Journal of Experimental Medicine·Silvia Schnyder-CandrianBruno Schnyder
Dec 7, 2007·Seminars in Immunology·Shean J AujlaJay K Kolls
Apr 11, 2008·Immunity·Mandy J McGeachy, Daniel J Cua
Sep 13, 2008·American Journal of Respiratory and Critical Care Medicine·Hidefumi WakashinHiroshi Nakajima
Aug 8, 2009·American Journal of Respiratory and Critical Care Medicine·Rhonda H WilsonDonald N Cook
Nov 26, 2009·Cell Research·Juan PengChen Dong
Aug 31, 2010·Nature Immunology·Stephane LajoieMarsha Wills-Karp
Mar 5, 2011·Experimental & Molecular Medicine·Yanchun LiJirong Lu
Oct 19, 2011·The Journal of Clinical Investigation·Ana Paula MoreiraCory M Hogaboam
Jun 9, 2012·International Archives of Allergy and Immunology·Giorgio CiprandiCarmelo Salpietro
Aug 29, 2012·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Q GuanZ Peng
Sep 11, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachael A Mintz-ColeGurjit K Khurana Hershey
Feb 21, 2013·Thorax·Dawn Catherine NewcombR Stokes Peebles
Mar 20, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margaret W KinyanjuiElizabeth D Fixman
Nov 10, 2013·American Journal of Respiratory and Critical Care Medicine·William W BusseShao-Lee Lin
May 9, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Katsunori MasakiKoichiro Asano
Aug 16, 2014·Respiratory Research·Emily M NakadaElizabeth D Fixman
Sep 3, 2014·American Journal of Respiratory Cell and Molecular Biology·Bao-Ping TianHua-Hao Shen