Distinct Effects of Motor Training on Resting-State Functional Networks of the Brain in Parkinson's Disease.

Neurorehabilitation and Neural Repair
Amgad DrobyAnat Mirelman

Abstract

Background. Nigrostriatal dopaminergic loss is a hallmark of Parkinson's disease (PD) pathophysiology, leading to motor Parkinsonism. Different intervention protocols have shown that motor and cognitive functions improvement in PD occur via the modulation of distinct motor and cognitive pathways. Objective. To investigate the effects of two motor training programs on the brains' functional networks in PD patients. Methods. Thirty-seven PD patients were prospectively studied. All enrolled patients underwent either treadmill training (TT) (n = 19) or treadmill with virtual reality (TT + VR) (n = 18) for 6 weeks. Magnetic resonance imaging (MRI) scans (3 T) acquiring 3-dimensional T1-weighted and resting-state functional MRI (rs-fMRI) data sets were performed at baseline and after 6 weeks. Independent component analysis (ICA) was conducted, and functional connectivity (FC) changes within large-scale functional brain networks were examined. Results. In both groups, significant post-training FC decrease in striatal, limbic, and parietal regions within the basal ganglia network, executive control network, and frontal-striatal network, and significant FC increase in the caudate, and cingulate within the sensorimotor network (SMN) were...Continue Reading

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Citations

Jun 9, 2021·Parkinsonism & Related Disorders·Daniel H LenchGonzalo J Revuelta

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Methods Mentioned

BETA
SMA

Software Mentioned

SPM
Statistical Package for Social Science ( SPSS
CONN
TT
GICA1
CONN toolbox
miniBEST
TIME
MoCA
DARTEL

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