PMID: 41588Nov 21, 1979

Distinct effects of three bile salts on cholesterol solubilization by oleate-monoolein-bile salt micelles

Biochimica Et Biophysica Acta
J C MontetA Gerolami

Abstract

Micellar cholesterol solubilities in bile salt-monoolein-oleic acid systems have been determined. Whatever the bile salt/oleyl compounds ratio, taurochenodeoxycholate solubilizes more cholesterol than taurocholate and much more than tauroursodeoxycholate. At pH 6.7, the cholesterol solubility limit is about the same with either oleate or monoolein. Cholesterol solubility falls in oleate-bile acid mixtures as the pH is raised. The capacity for supersaturation with cholesterol is greater for bile salt-monoolein than for bile salt-oleate micelles. For the latter it decreases as pH increases.

References

Nov 1, 1991·The British Journal of Nutrition·J KhallouC Lutton
Apr 1, 1982·Biochimie·J C MontetA Gerolami
Nov 1, 1989·Journal of Hepatology·K Y DaiA M Montet
Jul 13, 2002·Journal of Pharmaceutical Sciences·Timothy Scott Wiedmann, Lamya Kamel

Citations

Apr 13, 1979·Science·J S Patton, M C Carey
May 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·D H Neiderhiser, H P Roth

Related Concepts

Taurocholic Acid, Monolithium Salt
Monoolein
Epicholesterol
Bile Acid Measurement
Ursolite
Oleate
Oleic Acid
Acylglycerol
Bile Salts
Hydrogen-Ion Concentration

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