Distinct eGFR trajectories are associated with risk of myocardial infarction in people with diabetes or prediabetes.

Journal of Diabetes
Yingting ZuoYan He

Abstract

The relationship between estimated glomerular filtration rate (eGFR) trajectories and myocardial infarction (MI) has so far been unclear in people with diabetes or prediabetes. We aimed to identify common eGFR trajectories in people with diabetes or prediabetes and to examine their association with MI risk. The data of this analysis were derived from the Kailuan study, which was a prospective community-based cohort study. The eGFR trajectories of 24 723 participants from the year 2006 to 2012 were generated by latent mixture modeling. Cox proportional hazards models were used to calculate hazard ratios (HR) and their 95% CI for the subsequent risk of MI of different eGFR trajectories. We identified five distinct eGFR trajectories during 2006 to 2012 and named them according to their eGFR range and pattern over time: low-stable (9.4%), moderate-stable (31.4%), moderate-increasing (29.5%), high-decreasing (13.9%), and high-stable (15.8%). During a mean follow-up of 4.61 years, there were a total of 235 incident MI. Although the high-decreasing group had similar eGFR levels to the moderate-stable group during the last exposure period, the risk was much higher (adjusted HR, 3.57; 95% CI, 1.63-7.85 vs adjusted HR, 2.88; 95% CI, 1.36...Continue Reading

References

May 15, 1996·American Journal of Epidemiology·F J Nieto, J Coresh
Nov 8, 2003·Hypertension·Mark J SarnakUNKNOWN American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology,
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Nov 7, 2009·Journal of the American Society of Nephrology : JASN·Kunihiro MatsushitaJosef Coresh
Mar 3, 2010·Annual Review of Clinical Psychology·Daniel S Nagin, Candice L Odgers
Oct 16, 2010·Journal of the American Society of Nephrology : JASN·Ziyad Al-AlySeth Eisen
May 4, 2011·Nature Reviews. Nephrology·Juan F Navarro-GonzálezJavier García-Pérez
Jan 31, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Liang LiTom H Greene
Jan 25, 2013·Kidney International·Tanvir C TurinBrenda R Hemmelgarn
Sep 12, 2014·Journal of Pediatric Endocrinology & Metabolism : JPEM·Soha M Abd El DayemEsmat Abd El Ghaffar
Oct 28, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z LiX Zhao
Oct 11, 2015·International Journal of Cardiology·Tanvir C TurinBrenda R Hemmelgarn
Dec 15, 2015·Journal of the American Society of Nephrology : JASN·David M J NaimarkUNKNOWN CKD Prognosis Consortium
Dec 15, 2015·Journal of the American Society of Nephrology : JASN·Csaba P KovesdyUNKNOWN CKD Prognosis Consortium
Mar 22, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·J B Echouffo-TcheuguiB G Jaar
Nov 13, 2018·Kidney International·Guozhi JiangUNKNOWN Hong Kong Diabetes Register TRS Study Group
Dec 21, 2018·Circulation·Kristian ThygesenUNKNOWN Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American He

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