Distinct electrophysiological alterations in dentate gyrus versus CA1 glial cells from epileptic humans with temporal lobe sclerosis

Epilepsy Research
A Bordey, D D Spencer

Abstract

Previous studies have characterized the electrophysiological properties of astrocytes in the CA1 region of hippocampi resected from patients with intractable temporal lobe epilepsy (TLE). However, the properties of hilar astrocytes from such patients have not been studied although astrocytes display regional heterogeneity and a non-uniform response to injury. Thus, we performed patch-clamp recordings of putative astrocytes in hilar and CA1 regions of surgically removed epileptic hippocampi with and without sclerosis (mesial TLE, MTLE patients, and paradoxical TLE, PTLE patients, respectively), and non-epileptic, non-sclerotic hippocampi (tumor patients). Our data show that the current profile of hilar astrocytes undergoes significant changes in MTLE but not in PTLE or tumor hippocampi. In particular, inwardly rectifying K(+) (K(IR)) and outwardly rectifying K(+) currents were reduced, inward Na(+) currents and membrane resistances were increased in putative astrocytes from MLTE cases compared to PTLE and tumor cases. Because the conductance of K(IR) channels in cell-attached patches (approximately 34pS) from MTLE tissue was not altered, a reduction in the number of K(IR) channels likely accounts for the decrease in whole-cell K...Continue Reading

References

Jun 5, 1989·Neuroscience Letters·J G McLarnon, S U Kim
Feb 27, 1970·Science·D A Pollen, M C Trachtenberg
Oct 7, 1998·Epilepsy Research·A Bordey, H Sontheimer
Oct 9, 1999·Epilepsy Research·I BlümckeO D Wiestler
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D L DaviesK D Phelan
Mar 25, 2000·Neurochemistry International·W Walz
Jul 11, 2000·The European Journal of Neuroscience·S HinterkeuserC Steinhäuser
Feb 22, 2001·Annual Review of Physiology·A AraqueP G Haydon
May 19, 2001·Neurologic Clinics·I NajmD Janigro
Jan 1, 1992·The European Journal of Neuroscience·C. SteinhäuserH. Kettenmann
Oct 24, 2002·The Journal of Membrane Biology·K Gipson, A Bordey
Dec 6, 2003·The European Journal of Neuroscience·A Bordey, D D Spencer

❮ Previous
Next ❯

Citations

Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nihal C de LanerolleDennis D Spencer
Mar 8, 2008·Epilepsia·Ronald JabsChristian Steinhäuser
Jul 20, 2005·Epilepsia·Hui-Qiu WuRobert Schwarcz
Nov 15, 2015·Glia·Sergei KirischukBrian Billups
Aug 21, 2013·Pharmacological Reports : PR·Krzysztof Sendrowski, Wojciech Sobaniec
Feb 8, 2018·Pharmaceuticals·José J Jarero-BasultoCarlos Beas-Zarate
Feb 25, 2005·Brain : a Journal of Neurology·Anne WilliamsonHoby Hetherington
Aug 23, 2005·Journal of Neurobiology·Masako Isokawa, Guy M McKhann
Oct 6, 2020·Frontiers in Neurology·Allison R Peterson, Devin K Binder

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.