Abstract
Previous studies have characterized the electrophysiological properties of astrocytes in the CA1 region of hippocampi resected from patients with intractable temporal lobe epilepsy (TLE). However, the properties of hilar astrocytes from such patients have not been studied although astrocytes display regional heterogeneity and a non-uniform response to injury. Thus, we performed patch-clamp recordings of putative astrocytes in hilar and CA1 regions of surgically removed epileptic hippocampi with and without sclerosis (mesial TLE, MTLE patients, and paradoxical TLE, PTLE patients, respectively), and non-epileptic, non-sclerotic hippocampi (tumor patients). Our data show that the current profile of hilar astrocytes undergoes significant changes in MTLE but not in PTLE or tumor hippocampi. In particular, inwardly rectifying K(+) (K(IR)) and outwardly rectifying K(+) currents were reduced, inward Na(+) currents and membrane resistances were increased in putative astrocytes from MLTE cases compared to PTLE and tumor cases. Because the conductance of K(IR) channels in cell-attached patches (approximately 34pS) from MTLE tissue was not altered, a reduction in the number of K(IR) channels likely accounts for the decrease in whole-cell K...Continue Reading
References
Jan 1, 1989·Glia·J G McLarnon, S U Kim
Jun 5, 1989·Neuroscience Letters·J G McLarnon, S U Kim
Feb 27, 1970·Science·D A Pollen, M C Trachtenberg
Sep 14, 1984·Science·E A NewmanL L Odette
Oct 1, 1994·Pflügers Archiv : European journal of physiology·C SteinhäuserG Seifert
Nov 1, 1994·Glia·L D Shrode, R W Putnam
Oct 1, 1995·Glia·K KressinC Steinhäuser
Oct 1, 1995·Glia·S H LeeA H Cornell-Bell
Jul 1, 1997·Glia·M FranckeW Reichelt
Oct 23, 1997·Epilepsy Research·N C de LanerolleM L Brines
Jul 31, 1998·Neuroscience Letters·S GabrielU Heinemann
Oct 7, 1998·Epilepsy Research·A Bordey, H Sontheimer
Jan 23, 1999·Annals of Neurology·A WilliamsonD D Spencer
Oct 9, 1999·Epilepsy Research·I BlümckeO D Wiestler
Oct 26, 1999·Glia·W SchröderC Steinhäuser
Dec 14, 1999·Glia·A BringmannA Reichenbach
Mar 1, 2000·Glia·A Bordey, H Sontheimer
Mar 15, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D L DaviesK D Phelan
Mar 25, 2000·Neurochemistry International·W Walz
Jul 11, 2000·The European Journal of Neuroscience·A KiviS Gabriel
Jul 11, 2000·The European Journal of Neuroscience·S HinterkeuserC Steinhäuser
Sep 22, 2000·Epilepsia·W SchröderC Steinhäuser
Feb 22, 2001·Annual Review of Physiology·A AraqueP G Haydon
May 19, 2001·Neurologic Clinics·I NajmD Janigro
Jan 1, 1992·The European Journal of Neuroscience·C. SteinhäuserH. Kettenmann
Oct 24, 2002·The Journal of Membrane Biology·K Gipson, A Bordey
Dec 6, 2003·The European Journal of Neuroscience·A Bordey, D D Spencer
Citations
Oct 1, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nihal C de LanerolleDennis D Spencer
Mar 8, 2008·Epilepsia·Ronald JabsChristian Steinhäuser
Sep 24, 2010·Journal of Neurophysiology·Tessandra H StewartRaimondo D'Ambrosio
Jul 20, 2005·Epilepsia·Hui-Qiu WuRobert Schwarcz
Jul 28, 2013·Epilepsy Research·Xin QiaoErwin A van Vliet
Nov 15, 2015·Glia·Sergei KirischukBrian Billups
Aug 10, 2010·Neurobiology of Disease·D K TakahashiK S Wilcox
Sep 3, 2016·Neuroscience·Chelsea M GriffithPeter R Patrylo
Aug 21, 2013·Pharmacological Reports : PR·Krzysztof Sendrowski, Wojciech Sobaniec
Feb 8, 2018·Pharmaceuticals·José J Jarero-BasultoCarlos Beas-Zarate
Feb 25, 2005·Brain : a Journal of Neurology·Anne WilliamsonHoby Hetherington
Aug 23, 2005·Journal of Neurobiology·Masako Isokawa, Guy M McKhann
Oct 6, 2020·Frontiers in Neurology·Allison R Peterson, Devin K Binder