Distinct epitopes of Ik gene products identified by monoclonal antibodies

European Journal of Immunology
M PierresD Caillol

Abstract

Analysis of reactivity of monoclonal anti-Iak alloantibodies, obtained by fusion between NS 1 myeloma and spleen cells from alloimmune A. TH mice, permitted the identification of 9 distinct determinants of the Ik gene products. Competitive binding experiments indicated that 2 private epitopes (defined by H8-109.13 and H8-138.4 antibodies) of the I-Ak product could be separated, thereby apparently splitting the Ia.2 specificity. A public determinant of the I-Ak molecule (identified by H8-15.9 antibody) was found expressed not only on the I-A products of the H-2b, H-2d, H-2ja, H-2p and H-2q murine haplotypes, but also on human HLA-DR antigens. Four determinants of the I-E/Ck antigen (defined by H7-8.26, H10-81.10, H10-93.2 and H8-86.2 antibodies) had a strain distribution analogues to the Ia.7 specificity. However, competitive binding experiments, and the cross-reactivity pattern with Ia-like antigens from other species (e.g. human HLA-DR antigens) indicated that these antibodies detected distinct determinants on the I-E/Ck molecule, thereby subdividing the broad Ia. 7 specificity. Two other determinants (defined by H9-14.8 and H9-15.4 antibodies) had a strain distribution that did not permit a precise assignment to a given Ia an...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·B RubinM Hoier-Madsen
Jan 1, 1977·Scandinavian Journal of Immunology·P IványiG Petrányi
Jan 1, 1978·Immunological Reviews·B Benacerraf, R N Germain
May 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M PierresR N Germain
Jan 1, 1979·Scandinavian Journal of Immunology·J K LunneyD H Sachs
Jan 1, 1979·Immunological Reviews·F M BrodskyW F Bodmer
Jan 1, 1978·Journal of Immunological Methods·G A GutmanA Bowles
Oct 1, 1978·European Journal of Immunology·D W Mason, G G Gallico
Nov 1, 1972·The Journal of Experimental Medicine·R Lieberman, W Humphrey
Jan 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·P Coffino, M D Scharff
Mar 1, 1969·Transplantation·D B AmosA Tiilikainen

❮ Previous
Next ❯

Citations

Dec 1, 1981·Immunogenetics·P C DubreuilF A Lemonnier
Jan 1, 1982·Immunogenetics·W P LafuseC S David
Mar 1, 1982·Neurochemical Research·O K LangleyC Goridis
Jan 1, 1989·Immunogenetics·V Hauptfeld-Dolejsek, D C Shreffler
May 1, 1989·Molecular Immunology·R AstonG L Ada
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H CaillaJ Marti
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D HolmbergA Coutinho
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R N GermainJ Y Tou
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B MalissenL Hood
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G E ShaferC LeGuern
May 1, 1989·The Journal of Experimental Medicine·M PierresD Mathis
Sep 1, 1989·The Journal of Experimental Medicine·J C Cambier, K R Lehmann
Dec 1, 1987·Journal of Immunogenetics·D K MaleG W Butcher
Apr 1, 1987·Journal of Immunogenetics·G A HadleyD Steinmuller
Aug 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F R F NascimentoM Russo
Nov 1, 1981·Immunology Today·B Rubin, M Pierres
Aug 1, 1988·International Reviews of Immunology·J Klein
Dec 1, 1986·Scandinavian Journal of Immunology·P M MinoprioH Eisen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.