Distinct Expression and Prognostic Value of MS4A in Gastric Cancer

Open Medicine
Lei SunChao Zhang

Abstract

Gastric cancer has high malignancy and early metastasis, which lead to poor survival rate. In this study, we assessed the expressions and prognostic values of MS4A family, a newly recently discovered family, by two online dataset, GEPIA and Kaplan Meier-plotter. From these results eight members, MS4A2, MS4A6, MS4A7, MS4A8, MS4A14, MS4A15, TMEM176A and TMEM176B showed positive expression in gastric cancer or normal tissues, and these genes were screened for further analysis of prognostic values. We observed that low mRNA expressions of MS4A2, MS4A7, MS4A14, MS4A15, TMEM176A and TMEM176B were correlated with better overall survival (OS) in all gastric cancer patients, while high mRNA expression of MS4A6 was observed to be associated with good prognosis. MS4A8's high mRNA level was correlated to better OS in diffuse gastric cancer patients. Further, we estimated prognostic values of MS4A family in gastric cancer patients with different clinic-pathological features, including clinical stages, differentiation level, lymph node status and HER2 status. Our results indicate that these eight MS4A members can estimate prognosis in patients with different pathological groups. In conclusion, MS4A family members are potential biomarkers, an...Continue Reading

References

Oct 21, 2000·Gastroenterology·D G SilbergP G Traber
Oct 31, 2001·Immunogenetics·M C GingrasJ F Margolin
Sep 29, 2011·Journal of Clinical Pathology·Umberto MalapelleGiancarlo Troncone
Nov 10, 2011·The Journal of Antibiotics·Changmu KimBong-Sik Yun
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 4, 2015·Immunology and Cell Biology·Li Eon KuekMark D Hulett
Apr 18, 2015·Journal of Hematology & Oncology·Gerwin HellerRotraud Wieser
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xinling ZhouMin Wang
Jun 30, 2016·OncoTargets and Therapy·Kai LiYing Huang
Nov 3, 2016·Breast Cancer Research and Treatment·András LánczkyBalázs Győrffy
Jul 6, 2017·Epigenetics : Official Journal of the DNA Methylation Society·Dan GaoMingzhou Guo
Aug 5, 2017·Cancer Immunology Research·Dalam LyLi Zhang
Nov 16, 2017·Acta biochimica Polonica·Marzena Zalewska-ZiobZofia Ostrowska

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Citations

May 6, 2019·American Journal of Respiratory Cell and Molecular Biology·Mengning ZhengPixin Ran
Apr 17, 2020·Clinical and Experimental Immunology·M SegoviaM Hill

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Software Mentioned

KM plotter
GEPIA
PostgreSQL

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