Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient

Oncotarget
Nam Nhut PhanYen-Chang Lin

Abstract

Breast cancer is a dangerous disease that results in high mortality rates for cancer patients. Many methods have been developed for the treatment and prevention of this disease. Determining the expression patterns of certain target genes in specific subtypes of breast cancer is important for developing new therapies for breast cancer. In the present study, we performed a holistic approach to screening the mRNA expression of six members of the cell division cycle-associated gene family (CDCA) with a focus on breast cancer using the Oncomine and The Cancer Cell Line Encyclopedia (CCLE) databases. Furthermore, Gene Expression-Based Outcome for Breast Cancer Online (GOBO) was also used to deeply mine the expression of each CDCA gene in clinical breast cancer tissue and breast cancer cell lines. Finally, the mRNA expression of the CDCA genes as related to breast cancer patient survival were analyzed using a Kaplan-Meier plot. CDCA3, CDCA5, and CDCA8 mRNA expression levels were significantly higher than the control sample in both clinical tumor sample and cancer cell lines. These highly expressed genes in the tumors of breast cancer patients dramatically reduced patient survival. The interaction network of CDCA3, CDCA5, and CDCA8 wit...Continue Reading

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Citations

Oct 4, 2020·Molecular Biology Reports·Haotian LuLing Li
Aug 31, 2018·Frontiers in Genetics·Lushun YuanXinghuan Wang
Sep 11, 2019·Bioinformatics·Noemi Di NanniEttore Mosca
Mar 15, 2019·Breast Cancer Research and Treatment·Chengxiao YuYue Jiang
Nov 16, 2018·International Journal of Molecular Medicine·Chao CiWei Ding
Jan 8, 2021·Cancer Management and Research·Rui PengHan Guan
Apr 18, 2020·PLoS Computational Biology·Chengwen LuoZhangsheng Yu
Mar 30, 2021·Frontiers in Molecular Biosciences·Shan-Shan JiangXing-Wei Xie
Nov 7, 2021·Journal of Cellular and Molecular Medicine·Xiao-Han CuiXi-Hu Qin

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