PMID: 9161637Apr 1, 1997Paper

Distinct expression of cytokines and mitogenic inhibitory factors in semen of fertile and infertile men

American Journal of Reproductive Immunology : AJRI
M HuleihelM Glezerman

Abstract

To assess the effect of seminal plasma (SP) of fertile and infertile men on leukocyte mitogenic response, and the capability of sperm cells to produce IL-1. This study included four groups: fertile men (donors, normal), infertile men with azoospermia (azoo), oligo-terato-asthenozoospermia (OTA), and OTA with genital infection (OTA-inf). Mouse spleen cell proliferation in response to lipopolysaccharide (LPS) or Concanavalin-A (Con-A) was examined in the presence of SP from the above four groups. Supernatants (sup) and lysates (lys) of sperm cells from fertile and oligoteratoasthenospermic (OTA) men were evaluated for IL-1 bioactivity by specific bioassay. Seminal plasma (SP) of the four groups were shown to inhibit the mitogenic response of mouse spleen cells to LPS and Con-A. SP of fertile men was significantly more inhibitory than SP from infertile men. Sperm cells from fertile and OTA infertile men constitutively produced IL-1. Sperm cells of both groups produced similar levels of IL-1 as examined in the supernatants and lysates. Seminal plasma of fertile men had more inhibitory mitogenic activity than that of OTA. Sperm cells constitutively produce IL-1. It is possible that the factors involved in this inhibition are not onl...Continue Reading

References

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Citations

Jun 17, 2000·Fertility and Sterility·M HuleihelM Glezerman
May 4, 2002·Molecular and Cellular Endocrinology·Mahmoud Huleihel, Eitan Lunenfeld
Jul 2, 2014·Histochemistry and Cell Biology·Eleonora SalvoliniGiancarlo Balercia
Aug 3, 2006·The Veterinary Clinics of North America. Equine Practice·Kristina G Lu, Peter R Morresey
Dec 3, 2008·American Journal of Reproductive Immunology : AJRI·Roger BadiaPaz Martínez
Jul 26, 2015·Fertility and Sterility·Joana Vieira SilvaMargarida Fardilha
Jun 24, 2016·American Journal of Reproductive Immunology : AJRI·Kristian LeisegangRalf R Henkel
Apr 25, 2000·Biology of Reproduction·D ZeyseM Huleihel
Jan 18, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Mahmoud Abu ElheijaMahmoud Huleihel
Mar 20, 2002·American Journal of Reproductive Immunology : AJRI·Mahmoud HuleihelMoshe Mazor
Mar 1, 2002·Archives of Andrology·J PapadimasA Tourkantonis

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