Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules

Biological Chemistry
Mária TrexlerLászló Patthy

Abstract

We have recently identified a gene (the WFIKKN gene) on human chromosome 16 (16p13.3) that encodes a secreted protein containing WAP-type, Follistatin/ Kazal type, Kunitz-type and NTR-type protease-inhibitory modules and an Immunoglobulin domain [Trexler et al., Proc. Natl. Acad. Sci. USA 98 (2001), 3705 - 3709]. In the present work we show that a gene on chromosome 17 encodes a WFIKKN-related protein (WFIKKNRP) that has the same domain organization as the WFIKKN protein. The exon-intron structure of the two genes is also similar as both genes have a single phase 0 intron that splits their WAP domains in equivalent positions. In view of the presence of several protease inhibitory modules in these proteins it seems likely that they serve to control the action of multiple types of proteases. The tissue expression pattern of the two proteins, however, is markedly different suggesting that they have distinct biological roles. Whereas the WFIKKN gene is expressed primarily in adult pancreas, liver and thymus but not in brain and ovary, significant expression of the WFIKKNRP gene is observed in ovary, testis and brain, but not in liver. Pronounced differences could also be seen in the case of fetal tissues: expression of the WFIKKN g...Continue Reading

References

Oct 1, 1986·European Journal of Biochemistry·R HeinzelG Steffens
Apr 24, 1982·Nucleic Acids Research·L G Hennighausen, A E Sippel
Jun 1, 1995·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·G J Broze
Jan 1, 1997·Cellular and Molecular Life Sciences : CMLS·I Saxena, S Tayyab
May 23, 1998·Human Molecular Genetics·M Q Zhang
Jul 27, 1999·The Journal of Biological Chemistry·H J MägertW G Forssmann
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·M TrexlerL Patthy

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Citations

Sep 27, 2003·European Journal of Biochemistry·Jeffrey P BocockAnn H Erickson
Sep 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yun-Sil Lee, Se-Jin Lee
Jul 4, 2008·The Journal of Biological Chemistry·Katalin KondásLászló Patthy
Oct 11, 2012·BMC Genomics·Olivier MonestierVéronique Blanquet
Sep 1, 2012·PloS One·Olivier MonestierVéronique Blanquet
Nov 10, 2012·PloS One·Nirmal ChhikaraSavita Yadav
Apr 8, 2014·Gene·Jiqing WangJon G H Hickford
Aug 5, 2008·Trends in Immunology·Colin D Bingle, Annapurna Vyakarnam
Oct 22, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akiko T NishidaKei Tashiro
Sep 23, 2011·Biochemical Society Transactions·Colin D Bingle
Sep 23, 2011·Biochemical Society Transactions·Katalin KondásLászló Patthy
Jun 22, 2016·Cytokine & Growth Factor Reviews·Olivier Monestier, Véronique Blanquet
Oct 27, 2016·The FEBS Journal·György SzlámaLászló Patthy
Jul 23, 2015·Scientific Reports·Jiqing WangJon G H Hickford
Mar 5, 2017·BMC Biology·Ryan G WalkerThomas B Thompson
Jun 29, 2017·Developmental and Comparative Immunology·Suzanne SuleimanElisabeth A Dyrynda
Jun 23, 2006·Journal of Biomolecular NMR·Edvards LiepinshGottfried Otting
May 4, 2021·The Journal of Clinical Investigation·Se-Jin Lee

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