Distinct function of Th1 and Th2 type delayed type hypersensitivity: protective and pathological reactions to chlamydial infection

Microscopy Research and Technique
X Yang

Abstract

The role of delayed-type hypersensitivity (DTH) to chlamydial infection has been shown to be a double-edged sword to the host. Reported animal and human studies have, on the one hand, shown that DTH is associated with protective immunity against chlamydial infection and, on the other hand, shown links to immunopathology. Using a murine lung infection model, we recently demonstrated that there might be two different functional types of DTH induced by chlamydial infection based on its association with cytokine patterns. Th1 type DTH is associated with protection while Th2 type DTH is associated with immunopathology. The Th2 type DTH demonstrated in IFNgamma gene knockout (KO) mice is characterized by eosinophil infiltration in addition to mononuclear cell infiltration that exists in Th1 DTH, observed in wild-type C57BL/6 mice and IL-10 KO mice. In addition, the inflammatory cells in IFNgamma KO mice fail to target the cellular sites of chlamydial inclusions in infected tissues and fail to clear the infection. The functional differences in Th1 and Th2 type DTH responses may account for the dual role DTH plays in chlamydial protective immunity and immunopathology.

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Citations

Jun 12, 2003·Fertility and Sterility·Joseph DebattistaJanet Allan
Nov 19, 2003·American Journal of Veterinary Research·Wolf von BomhardAndreas Pospischil
Jun 11, 2014·Developmental and Comparative Immunology·Marina MathewAdam Polkinghorne
Dec 13, 2005·Microbiological Research·Philomène Mpiga, Madeleine Ravaoarinoro
Aug 28, 2015·Clinical Microbiology Reviews·S MenonW M Huston
Feb 4, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lili ChenGuangming Zhong
Jun 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lei JiaoXi Yang
May 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthew D WoolardJerry W Simecka
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura BilenkiXi Yang

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