Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis

Frontiers in Neurology
Sabrina GoldeStefan M Gold

Abstract

Objective: Multiple sclerosis (MS) is characterized by impairments in basic cognitive functions such as information processing speed as well as in more complex, higher-order domains such as social cognition. However, as these deficits often co-occur, it has remained challenging to determine whether they have a specific pathological basis or are driven by shared biology. Methods: To identify neural signatures of social cognition deficits in MS, data were analyzed from n = 29 patients with relapsing-remitting MS and n = 29 healthy controls matched for age, sex, and education. We used neuropsychological assessments of information processing speed, attention, learning, working memory, and relevant aspects of social cognition (theory of mind, emotion recognition (ER), empathy) and employed neuroimaging of CNS networks using resting-state functional connectivity. Results: MS patients showed significant deficits in verbal learning and memory, as well as implicit ER. Performance in these domains was uncorrelated. Functional connectivity analysis identified a distinct network characterized by significant associations between poorer ER and lower connectivity of the fusiform gyrus (FFG) with the right lateral occipital cortex, which also ...Continue Reading

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Citations

Feb 3, 2021·The International Journal of Neuroscience·Triantafyllos DoskasΚonstantinos Vadikolias
Apr 27, 2021·Frontiers in Psychiatry·XiaoGuang LinZhongQuan Yi
Jun 26, 2021·Acta Neuropathologica·Valeria RamagliaMaarten H P Kole

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Software Mentioned

MATLAB
DPARSFA
Statistical Parametric Mapping program
FSL FLAMEO
FSL
Diffusion Toolbox
Movie for the Assessment of Social Cognition ( MASC )
R
FacePuzzle
SPSS Statistics

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