Feb 22, 2012

Distinct functional networks within the cerebellum and their relation to cortical systems assessed with independent component analysis

NeuroImage
Vitaly I DobromyslinRegina E McGlinchey

Abstract

Cerebellar functional circuitry has been examined in several prior studies using resting fMRI data and seed-based procedures, as well as whole-brain independent component analysis (ICA). Here, we hypothesized that ICA applied to functional data from the cerebellum exclusively would provide increased sensitivity for detecting cerebellar networks compared to previous approaches. Consistency of group-level networks was assessed in two age- and sex-matched groups of twenty-five subjects each. Cerebellum-only ICA was compared to the traditional whole-brain ICA procedure to examine the potential gain in sensitivity of the novel method. In addition to replicating a number of previously identified cerebellar networks, the current approach revealed at least one network component that was not apparent with the application of whole brain ICA. These results demonstrate the gain in sensitivity attained through specifying the cerebellum as a target structure with regard to the identification of robust and reliable networks. The use of similar procedures could be important in further expanding on previously defined patterns of cerebellar functional anatomy, as well as provide information about unique networks that have not been explored in pr...Continue Reading

Mentioned in this Paper

Fluctuation
Entire Red Nucleus
Biologic Segmentation
Hemispheral Lobule IX
Cortex Bone Disorders
Adrenal Cortex Diseases
Lobule
Occipital Lobe
Prefrontal Cortex
Projections and Predictions

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