Distinct genetic alterations in pediatric glioblastomas.

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Sun-ju ByeonSung-Hye Park

Abstract

Pediatric high-grade tumors, especially glioblastomas (GBs), can be clinically devastating but are under-studied in comparison with adult GBs (aGBs). Molecular features of pediatric GBs (pGBs) are poorly understood and novel-targeted therapies have not been routinely used in pediatric patients with GBs. Twenty-four non-brainstem pGBs were studied. To compare pGBs with aGBs, immunohistochemical staining and fluorescent in situ hybridization were performed in paraffin-embedded tissues. Microarray gene expression analyses were performed in snap-frozen tissues of four primary pGBs, six primary aGBs, and one non-neoplastic brain. Immunohistochemial p16 loss was more frequent in pGBs, whereas p53, epidermal growth factor receptor, and phosphatase and tensin homolog loss were similar to that of aGBs. No case was isocitrate dehydrogenase (IDH)1 immunopositive or showed the IDH1 R132/IDH2 R172 mutation, suggesting primary GB. Microarray analysis revealed two pGB subtypes (A and B). Type B pGBs and aGBs had similar gene expression profiles; however, the profiles of type A pGBs differed from those of aGBs. In type A pGBs, we identified 90 up- and 63 down-regulated genes; platelet-derived growth factor receptor α polypeptide and CCND2 expr...Continue Reading

References

Apr 13, 1999·Archives of Neurology·R J Packer
Nov 30, 2000·Current Treatment Options in Neurology·R J Packer
May 5, 2005·Journal of the National Cancer Institute·Federico CappuzzoMarileila Varella-Garcia
Apr 3, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Damien FauryNada Jabado
Nov 5, 2008·Neuro-oncology·Vaishali SuriChitra Sarkar
Nov 27, 2008·Neuro-oncology·Ramandeep S AroraJillian M Birch
Sep 10, 2009·Cancer Science·Hiroko Ohgaki, Paul Kleihues
Sep 10, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dorine A BaxChris Jones
Feb 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam ZarghooniCynthia Hawkins
May 6, 2010·Journal of the Neurological Sciences·Bomi KimSung-Hye Park
May 19, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara S PaughSuzanne J Baker
Jul 14, 2010·Experimental and Molecular Pathology·S SharmaJ K Cowell
Aug 3, 2010·Journal of Neurosurgery. Pediatrics·Kyung Sun SongSeung-Ki Kim
Mar 9, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Sumihito NobusawaHiroko Ohgaki
Jul 27, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ji Yeoun LeeSeung-Ki Kim

❮ Previous
Next ❯

Citations

May 1, 2013·Genes & Development·Julie-Aurore Losman, William G Kaelin
Jul 31, 2013·Neurologic Clinics·Rimas V Lukas, Martin Kelly Nicholas
Jan 16, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hadie AdamsAlfredo Quiñones-Hinojosa
Oct 31, 2015·Neuro-oncology·John H Sampson, Duane A Mitchell
Jun 13, 2015·Cancer Control : Journal of the Moffitt Cancer Center·Robert J Macaulay

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.