Distinct Histologic, Immunohistochemical and Clinical Features Associated With Serous Endometrial Intraepithelial Carcinoma Involving Polyps.

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Vincent Q-H TrinhKurosh Rahimi

Abstract

The origin of serous endometrial intraepithelial carcinoma (SEIC) is debated, due to its premalignant and independently malignant nature. It often arises next to endometrial serous carcinoma (ESC), with a propensity for polypoid growth. We aimed to better characterize this discrepancy by analyzing the clinical, histologic, and immunohistochemical features of polypoid carcinoma associated with SEIC (P-SEIC), and compared them with usual endometrial serous carcinoma without SEIC (UESC). Consecutive patients with P-SEIC were recruited and compared with UESC controls from our institutional research center. Clinical, histologic, and immunohistochemical (IHC, ER, PR, P53, Napsin-A, WT1, P16) were analyzed. BRCA testing results and familial history were also extracted from clinical databases. Welch T test, Pearson χ, and Fisher exact test were performed in SPSS version 23. A total of 37 P-SEIC and 25 UESC were the basis of a case-control study. P-SEIC was associated with more bilateral ovarian involvement (P=0.026), yet showed lower rates of myometrial invasion (P=0.002). P-SEIC showed a statistically different IHC profile: p53+, p16+, ER+, PR+, and WT-1+, and high rates of Napsin-A, while UESC was p53+, p16+, WT-1-, Napsin-A-, with l...Continue Reading

References

Jun 1, 1992·The American Journal of Surgical Pathology·M E ShermanR J Kurman
Apr 1, 1995·The American Journal of Surgical Pathology·G W Spiegel
May 9, 2000·The American Journal of Surgical Pathology·R A SoslowC Isacson
Jun 2, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Elke A JarboeMarisa R Nucci
May 1, 2010·The American Journal of Surgical Pathology·Elisabetta KuhnIe-Ming Shih
Feb 12, 2011·Seminars in Diagnostic Pathology·Robert A Soslow
Apr 6, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Nisreen AbushahinWenxin Zheng
Jan 18, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Thijs RoelofsenLeon F A G Massuger
Feb 10, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shangguo TangDean Daya
Aug 28, 2012·Journal of the National Cancer Institute·Elisabetta KuhnIe-Ming Shih
Nov 22, 2012·Obstetrics and Gynecology·Thijs RoelofsenJohan Bulten
Feb 19, 2013·Diagnostic Pathology·Masanori YasudaYoichi Kameda
May 3, 2013·Nature·Cyriac KandothDouglas A Levine
May 30, 2014·The Lancet Oncology·Rajmohan MuraliBritta Weigelt
Jul 19, 2014·Human Pathology·Catherine HedleyMona El-Bahrawy
Dec 5, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mary C TolcherSean C Dowdy
Dec 31, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sonia Gatius, Xavier Matias-Guiu
Jul 23, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Elisabetta KuhnIe-Ming Shih

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
hysterectomy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Jonathan L HechtRobert A Soslow
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Jamie MagrillFriedrich Kommoss
Obstetrical & Gynecological Survey
Charles J DuntonE Hernandez
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Chensi OuyangJune Y Hou
The American Journal of Surgical Pathology
Mitchell S Wachtel
© 2022 Meta ULC. All rights reserved