Distinct histone modifications denote early stress-induced drug tolerance in cancer.

Oncotarget
Abdullah Al EmranH Schaider

Abstract

Besides somatic mutations or drug efflux, epigenetic reprogramming can lead to acquired drug resistance. We recently have identified early stress-induced multi-drug tolerant cancer cells termed induced drug-tolerant cells (IDTCs). Here, IDTCs were generated using different types of cancer cell lines; melanoma, lung, breast and colon cancer. A common loss of the H3K4me3 and H3K27me3 and gain of H3K9me3 mark was observed as a significant response to drug exposure or nutrient starvation in IDTCs. These epigenetic changes were reversible upon drug holidays. Microarray, qRT-PCR and protein expression data confirmed the up-regulation of histone methyltransferases (SETDB1 and SETDB2) which contribute to the accumulation of H3K9me3 concomitantly in the different cancer types. Genome-wide studies suggest that transcriptional repression of genes is due to concordant loss of H3K4me3 and regional increment of H3K9me3. Conversely, genome-wide CpG site-specific DNA methylation showed no common changes at the IDTC state. This suggests that distinct histone methylation patterns rather than DNA methylation are driving the transition from parental to IDTCs. In addition, silencing of SETDB1/2 reversed multi drug tolerance. Alterations of histone ...Continue Reading

References

Mar 16, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Cara, I F Tannock
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·J R Dobosy, E U Selker
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Oct 25, 2003·Oncogene·Tito Fojo, Susan Bates
Dec 18, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T KurataM Fukuoka
Feb 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nikolai N KhodarevRalph R Weichselbaum
Mar 9, 2004·The Lancet Oncology·Helen K BerriemanLynn Cawkwell
Jan 11, 2005·The Journal of Pathology·D B Longley, P G Johnston
Feb 24, 2006·British Journal of Cancer·R M GlasspoolR Brown
Nov 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Ralph R WeichselbaumAndy J Minn
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jul 20, 2010·Bioinformatics·W J KentD Karolchik
Mar 21, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert J MotzerRobert A Figlin
Jul 10, 2012·Cell·Mark A Dawson, Tony Kouzarides
Sep 1, 2012·Nature Protocols·Jianxing FengXiaole Shirley Liu
Sep 4, 2013·Nature Reviews. Clinical Oncology·Elizabeth A KuczynskiRobert S Kerbel
Nov 29, 2013·Archives of Pathology & Laboratory Medicine·Ronghui XiaJiang Li
May 7, 2014·Nucleic Acids Research·Fidel RamírezThomas Manke
Aug 20, 2014·Genome Research·Anna SawickaChristian Seiser
Feb 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lishuang WangShiyu Han
Feb 20, 2015·Nature·UNKNOWN Roadmap Epigenomics ConsortiumManolis Kellis
Jul 3, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy V PaschallKebin Liu
Mar 19, 2016·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Arjen H G ClevenJudith V M G Bovée
Apr 5, 2016·The Journal of Clinical Investigation·Gao ZhangMeenhard Herlyn

❮ Previous
Next ❯

Citations

Jan 24, 2019·Cellular and Molecular Life Sciences : CMLS·Lía MayorgaMaría Roqué
Mar 10, 2019·Clinical Epigenetics·Joachim TorranoHelmut Schaider
Oct 5, 2019·Cancers·Mehwish Khaliq, Mohammad Fallahi-Sichani
Jul 2, 2020·International Journal of Molecular Sciences·Anna M CzarneckaPiotr Rutkowski
Oct 23, 2019·Cancer Informatics·Divya NivedithaShibasish Chowdhury
Feb 13, 2020·International Journal of Molecular Sciences·Shannon LeeWalter Kolch
Jul 1, 2020·F1000Research·Shensi Shen, Jean Clairambault
Apr 3, 2020·International Journal of Oncology·Florencia Paula Madorsky RowdoJosé Mordoh
Jul 7, 2020·Frontiers in Cell and Developmental Biology·Minjeong YeonDooil Jeoung
Dec 30, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Nirmalya Saha, Andrew G Muntean
Apr 1, 2021·Clinical Epigenetics·Federica SarnoUNKNOWN International Network Medicine Consortium
Apr 4, 2021·Cancers·Yelyzaveta ShlyakhtinaMaximiliano M Portal
Mar 31, 2021·The Journal of Investigative Dermatology·Abdullah Al EmranJessamy C Tiffen
Nov 12, 2018·Biochemical Pharmacology·François M ValletteDominique Heymann
Dec 29, 2020·Seminars in Cancer Biology·Urszula Oleksiewicz, Marta Machnik
Aug 28, 2021·Cells·Emilio Francesco Giunta On Behalf Of Scito Youth
Aug 15, 2021·Molecular Cancer Research : MCR·Camille LeonceSandra Ortiz-Cuaran
Jan 11, 2022·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Agnes MendoncaChongli Yuan

❮ Previous
Next ❯

Methods Mentioned

BETA
protein array
ChIP-seq
xenograft
biopsies
chips
immunoprecipitation
enzymatic shearing

Software Mentioned

Picard Tools
BigWig
R
R package methylumi
bedGraphToBigWig
R package minfi
R package “ lumi ”
deepTools webserver
Bioconductor package
R package

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.