Distinct histopathological features of Hashimoto's thyroiditis with respect to IgG4-related disease

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Yaqiong LiKennichi Kakudo

Abstract

A form of Hashimoto's thyroiditis with lymphoplasmacytic sclerosing changes and increased numbers of IgG4-positive plasma cells has recently been reported in the literature. These histopathological features suggest that this subtype of Hashimoto's thyroiditis may be closely related to IgG4-related disease. Therefore, this unique form of IgG4-related Hashimoto's thyroiditis, which is referred to as IgG4 thyroiditis, has its own clinical, serological, and sonographic features that are distinct from those associated with non-IgG4 thyroiditis. IgG4 thyroiditis shares similarities with the well-known fibrous variant of Hashimoto's thyroiditis; however, the detailed histopathological features of IgG4 thyroiditis have not been well established. Based on immunostaining results, 105 patients with Hashimoto's thyroiditis were divided into an IgG4 thyroiditis group (n=28) and a non-IgG4 thyroiditis group (n=77). As in our previous reports, IgG4 thyroiditis was associated with a patient population of a younger age, a lower female-to-male ratio, rapid progression, higher levels of thyroid autoantibodies, subclinical hypothyroidism, and diffuse sonographic echogenicity. Histopathologically, this group revealed severe lymphoplasmacytic infilt...Continue Reading

References

Feb 1, 1991·Journal of Endocrinological Investigation·S Sostre, M M Reyes
Feb 1, 1986·Journal of Clinical Ultrasound : JCU·N HayashiK Endo
Dec 1, 1985·Mayo Clinic Proceedings·I D Hay
Mar 1, 1974·Human Pathology·S M Katz, A L Vickery
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·V A LiVolsi
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Mar 21, 2002·Journal of the American Dietetic Association·Nancy S WellmanJean L Lloyd
Jun 27, 2003·The New England Journal of Medicine·Elizabeth N PearceLewis E Braverman
Nov 14, 2003·Journal of Gastroenterology·Terumi KamisawaHitoshi Nakajima
Jan 23, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shin-ichi TakedaEisuke Takazakura
May 18, 2005·The American Journal of Surgical Pathology·Satoshi KitagawaYasuni Nakanuma
Jul 1, 2005·Digestive Diseases and Sciences·Kenichi KomatsuShigeyuki Kawa
Jun 16, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yoh ZenYasuni Nakanuma
Jan 29, 2008·The American Journal of Surgical Pathology·Satomi KasashimaYasuni Nakanuma
Jul 9, 2008·World Journal of Gastroenterology : WJG·Terumi Kamisawa, Atsutake Okamoto
Aug 29, 2009·Pathology International·Yaqiong LiKennichi Kakudo
Aug 11, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Takashi OzakiShioko Kimura
Aug 25, 2010·Advances in Anatomic Pathology·Wah Cheuk, John K C Chan
Nov 26, 2010·The American Journal of Surgical Pathology·Yoh Zen, Yasuni Nakanuma
Dec 3, 2010·Current Opinion in Rheumatology·Arezou Khosroshahi, John H Stone
Aug 13, 2011·The Journal of Clinical Endocrinology and Metabolism·James V Hennessey
Sep 2, 2011·Modern Rheumatology·Hisanori UmeharaUNKNOWN Research Program for Intractable Disease by Ministry of Health, Labor and Welfare (MHLW) Japan G4 team

❮ Previous
Next ❯

Citations

Jun 12, 2013·Thyroid : Official Journal of the American Thyroid Association·Eijun NishiharaAkira Miyauchi
Jan 2, 2014·Case Reports in Endocrinology·G IannaciS Spiezia
Sep 3, 2013·Thyroid : Official Journal of the American Thyroid Association·Jing ZhangBingyin Shi
May 23, 2013·Endocrine·Sachiko-Tsukamoto KawashimaAkira Shimatsu
Jul 12, 2014·Virchows Archiv : an International Journal of Pathology·José Cameselle-TeijeiroAndrés Beiras-Iglesias
Dec 4, 2012·Journal of Clinical Pathology·Sean R WilliamsonLiang Cheng
Nov 18, 2014·Clinical Endocrinology·Emre BozkirliMelek Eda Ertorer
Dec 17, 2015·Virchows Archiv : an International Journal of Pathology·Friedrich JokischMarcus Kremer
Mar 26, 2015·Head and Neck Pathology·Vikram Deshpande
Dec 20, 2014·Virchows Archiv : an International Journal of Pathology·Jan LacoAleš Ryška
May 1, 2016·Annals of Diagnostic Pathology·Adriana Handra-Luca, Ema Dragoescu
Dec 23, 2016·Journal of Cancer Research and Clinical Oncology·T M P B TennakoonR S Dassanayake
May 2, 2017·Internal Medicine·Keiichi TorimotoYoshiya Tanaka
Oct 25, 2017·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Serap YucelDilek Saglam
Aug 15, 2017·Thyroid : Official Journal of the American Thyroid Association·Sung Hoon YuSeong Jin Lee
Mar 20, 2019·European Journal of Endocrinology·Mario RotondiLuca Chiovato
Jun 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Wenli LiJinming Li
Dec 13, 2012·Advances in Anatomic Pathology·Rahat M Bhatti, Edward B Stelow
Oct 30, 2014·The American Journal of Surgical Pathology·Giovanni Fellegara, Juan Rosai
Jan 31, 2018·Diagnostic Pathology·Yasuhiro Sakai, Yoshiaki Imamura
Dec 4, 2014·Arquivos brasileiros de endocrinologia e metabologia·Henrique Vara LuizJorge Portugal
Dec 22, 2019·Thyroid : Official Journal of the American Thyroid Association·Yaqiong LiKennichi Kakudo
Jun 25, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jarkko LintusaariIvana Kholová
Nov 24, 2019·Pathology·Shigeo Nakamura, Maurilio Ponzoni
Dec 26, 2018·Clinics and Practice·Ana E SirventLuis Jiménez Del Cerro
Mar 3, 2021·BMJ Case Reports·Tânia MatosSónia do Vale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.