Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling

Nature Communications
Pragya Goel, Dion Dickman

Abstract

Synapses are constructed with the stability to last a lifetime, yet sufficiently flexible to adapt during injury. Although fundamental pathways that mediate intrinsic responses to neuronal injury have been defined, less is known about how synaptic partners adapt. We have investigated responses in the postsynaptic cell to presynaptic activation of the injury-related Dual Leucine Zipper Kinase pathway at the Drosophila neuromuscular junction. We find that the postsynaptic compartment reduces neurotransmitter receptor levels, thus depressing synaptic strength. Interestingly, this diminished state is stabilized through distinct modulations to two postsynaptic homeostatic signaling systems. First, a retrograde response normally triggered by reduced receptor levels is silenced, preventing a compensatory enhancement in presynaptic neurotransmitter release. However, when global presynaptic release is attenuated, a postsynaptic receptor scaling mechanism persists to adaptively stabilize this diminished neurotransmission state. Thus, the homeostatic set point of synaptic strength is recalibrated to a reduced state as synapses acclimate to injury.

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Citations

Sep 27, 2019·Synapse·C Andrew FrankMartin Müller
Mar 28, 2019·The Journal of Cell Biology·Pragya GoelDion Dickman
Jul 8, 2020·Cells·Preethi Poovathumkadavil, Krzysztof Jagla
Jan 16, 2021·Cellular and Molecular Life Sciences : CMLS·Pragya Goel, Dion Dickman
Mar 3, 2021·Current Biology : CB·Niraja RameshStephan J Sigrist
Nov 14, 2020·Nature Reviews. Neuroscience·Mary T Joy, S Thomas Carmichael

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