Distinct inflammatory profile in preeclampsia and postpartum preeclampsia reveal unique mechanisms

Biology of Reproduction
Marie-Eve BrienSylvie Girard

Abstract

Preeclampsia (PE) is a poorly understood pregnancy complication. It has been suggested that changes in the maternal immune system may contribute to PE, but evidence of this remains scarce. Whilst PE is commonly experienced prepartum, it can also occur in the postpartum period (postpartum PE-PPPE), and the mechanisms involved are unknown. Our goal was to determine whether changes occur in the maternal immune system and placenta in pregnancies complicated with PE and PPPE, compared to normal term pregnancies. We prospectively recruited women and collected blood samples to determine the circulating immune profile, by flow cytometry, and assess the circulating levels of inflammatory mediators and angiogenic factors. Placentas were collected for histological analysis. Levels of alarmins in the maternal circulation showed increased uric acid in PE and elevated high-mobility group box 1 in PPPE. Analysis of maternal immune cells revealed distinct profiles in PE vs PPPE. PE had increased percentage of lymphocytes and monocytes whilst PPPE had elevated NK and NK-T cells as well. Elevated numbers of immune cells (CD45+) were detected in placentas from women that developed PPPE, and those were macrophages (CD163+). This work reveals chang...Continue Reading

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Citations

Jun 9, 2019·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Katherine LeaveyDavid Grynspan
Apr 25, 2020·The Journal of Physiology·Helena C ParkingtonShaun P Brennecke
Aug 8, 2020·American Journal of Reproductive Immunology : AJRI·Marie-Eve BrienSylvie Girard
Jul 31, 2019·International Journal of Molecular Sciences·Polina VishnyakovaGennady Sukhikh
May 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zhaochun LiuPing Wang
Oct 22, 2020·Mediators of Inflammation·Michał MichalczykRafał Rzepka
Apr 14, 2021·Journal of Leukocyte Biology·Derek MillerNardhy Gomez-Lopez
Aug 11, 2021·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sun Kwon KimRay O Bahado-Singh

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