Distinct mechanisms of platelet aggregation as a consequence of different shearing flow conditions

The Journal of Clinical Investigation
S GotoZaverio M Ruggeri

Abstract

Platelet aggregation contributes to arresting bleeding at wound sites, but may cause occlusion of atherosclerotic vessels, thus curtailing blood flow to vital organs. According to current dogma, the integrin alphaIIbbeta3 plays an exclusive role in linking platelets to one another through interactions with fibrinogen or vWf. We demonstrate here that, depending on shearing flow conditions, this process may require vWf binding to glycoprotein Ibalpha, even when alphaIIbbeta3 is competent to bind adhesive ligands. Platelet activation induced solely by high shear stress is initiated by glycoprotein Ibalpha interaction with vWf, but results in aggregation only if the latter can bind concurrently to alphaIIbbeta3. In contrast, platelets exposed to high shear rate after activation by exogenous agonists such as ADP and epinephrine can aggregate when fibrinogen is the alphaIIbbeta3 adhesive ligand, yet only if vWf binding to glycoprotein Ibalpha can also occur. Thus, the latter interaction appears to provide a bond with biomechanical properties necessary to overcome the effects of high shear rate and initiate interplatelet cohesion. These findings highlight the distinct function of two adhesive receptors mediating platelet aggregation u...Continue Reading

References

Sep 11, 1975·The New England Journal of Medicine·H J Weiss
Jan 1, 1977·Journal of Biomechanics·L D BackD W Crawford
Sep 18, 1975·The New England Journal of Medicine·H J Weiss
Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Nov 1, 1991·The Journal of Clinical Investigation·M H KrollA I Schafer
Aug 2, 1990·Nature·T A Springer
Apr 1, 1991·The Journal of Clinical Investigation·Y IkedaI Itagaki
Jul 1, 1983·The Journal of Clinical Investigation·Z M RuggeriR R Montgomery
Jun 8, 1995·The New England Journal of Medicine·J LefkovitsE J Topol
Jul 12, 1996·Science·T G DiacovoU H von Andrian

❮ Previous
Next ❯

Citations

Feb 15, 2002·International Journal of Hematology·Mitsuhiko Sugimoto, Shigeki Miyata
Nov 7, 2007·Annals of Biomedical Engineering·Anna M FallonAjit P Yoganathan
Jan 17, 2008·Annals of Biomedical Engineering·Michael A Johnson, Julia M Ross
Jan 29, 1999·Lancet·E J TopolE F Plow
Jan 22, 2004·Critical Reviews in Oncology/hematology·Indra Ramasamy
May 3, 2003·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Heyu Ni, John Freedman
Apr 19, 2005·Nature Medicine·Shaun P JacksonHatem H Salem
Mar 2, 1999·British Journal of Haematology·D H Bevan
Sep 21, 2000·British Journal of Haematology·P NurdenA Nurden
May 31, 2001·Clinical and Experimental Pharmacology & Physiology·S M DopheideS P Jackson
Jan 17, 2004·Seminars in Hematology·Barbara Plaimauer, Friedrich Scheiflinger
Jan 22, 2005·Seminars in Hematology·Grazia Loredana Mendolicchio, Zaverio M Ruggeri
Aug 30, 2008·The New England Journal of Medicine·Bruce Furie, Barbara C Furie
Mar 9, 2006·Hematology·Massimo Franchini
Jan 8, 2003·The Journal of Experimental Medicine·Steffen MassbergBernhard Nieswandt
Aug 29, 2000·Current Opinion in Hematology·T J Raife, R R Montgomery
Oct 18, 2001·Current Opinion in Hematology·B SavageZ M Ruggeri
Mar 15, 2006·Journal of Biomechanical Engineering·Anna M FallonStephen R Hanson
Mar 8, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·N LinderD Varon
Oct 16, 2008·Journal of Biomaterials Science. Polymer Edition·Min ZhangThomas A Horbett
Dec 3, 2005·The Journal of Clinical Investigation·Bruce Furie, Barbara C Furie
Mar 23, 2000·The Journal of Clinical Investigation·S KulkarniS P Jackson
Mar 23, 2000·The Journal of Clinical Investigation·Z M Ruggeri
Dec 2, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuomi KarioKazuyuki Shimada
Nov 2, 2005·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Steven R Steinhubl, David J Moliterno
Sep 3, 2013·Antioxidants & Redox Signaling·Francesco Violi, Pasquale Pignatelli
Jul 12, 2014·Heat and Mass Transfer = Wärme- Und Stoffübertragung·Jin LiuRavi Radhakrishnan
Apr 2, 2003·The Journal of Cell Biology·Warwick S NesbittShaun P Jackson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.