Distinct Metabolic Profiles are Associated with Colorectal Adenomas and Serrated Polyps

Obesity
Naomi Fliss-IsakovRevital Kariv

Abstract

Prevention of colorectal cancer (CRC) by colonoscopy is recommended according to age and personal/familial history. Metabolic alterations are associated with colorectal adenomas, but data are scarce regarding serrated polyps and advanced polyps. The aim of this study was to evaluate the association between metabolic alterations and colorectal polyp type and advanced polyps. A case-control study was conducted among consecutive subjects, 40 to 70 years old, who underwent screening/diagnostic colonoscopy from 2010 to 2015. Subjects who were treated for diabetes, who had a family/personal history of CRC, and who were at high risk for CRC were excluded. Participants underwent anthropometric, laboratory, and ultrasonographic evaluations and a medical and lifestyle interview. Polyps were histologically classified as adenomatous or serrated polyps and divided into advanced and non-advanced categories. The study included 828 participants (58.4 ± 6.6 years, 50.4% men). Abdominal obesity (odds ratio [OR] = 1.67, 95% CI: 1.20-2.30), hypertension (OR = 1.47, 95% CI: 1.03-2.09), and a high glycosylated hemoglobin percentage (HbA1c%) (OR = 1.57, 95% CI: 1.06-2.34) were independently associated with colorectal adenomas, whereas a high triglyce...Continue Reading

References

Aug 19, 2007·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N TravierN Pearce
May 13, 2008·Diabetes & Metabolism·Ivan Berlin
Jul 18, 2008·Carcinogenesis·Eleanor I AgerChristopher Christophi
Mar 24, 2009·AJR. American Journal of Roentgenology·Muriel WebbRan Oren
May 12, 2009·The Medical Clinics of North America·Camila ManriqueJames R Sowers
Jun 9, 2009·Diabetes Care·UNKNOWN International Expert Committee
Feb 18, 2011·Journal of Clinical Gastroenterology·Joseph Carl AndersonPetr Protiva
May 6, 2011·BMC Medicine·Eva KassiGeorge Chrousos
Feb 24, 2012·The New England Journal of Medicine·Ann G ZauberJerome D Waye
Oct 20, 2012·American Journal of Epidemiology·Zhenming FuWei Zheng
Jan 24, 2013·Histopathology·Mark BettingtonVicki Whitehall
Mar 6, 2013·American Journal of Epidemiology·Andrea N Burnett-HartmanPolly A Newcomb
Jul 19, 2013·International Journal of Molecular Sciences·Takahiro KochiHisataka Moriwaki
Mar 22, 2014·Molecular and Clinical Oncology·Nuengruetai OrannapalaiSurasak Sangkhathat
Apr 3, 2014·International Journal of Cancer. Journal International Du Cancer·Naoyoshi NagataNaomi Uemura
Aug 26, 2014·Journal of the Chinese Medical Association : JCMA·Chung-Chi LinWan-Leong Chan
Dec 3, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Han-Mo ChiuMing-Shiang Wu
Mar 18, 2015·Hormone Molecular Biology and Clinical Investigation·Katharina Nimptsch, Tobias Pischon
May 13, 2015·Nature Reviews. Gastroenterology & Hepatology·Joep E G IJspeertEvelien Dekker
Sep 12, 2015·Journal of Digestive Diseases·Yoshitaka WatanabeKazuhiko Koike
Sep 17, 2015·Endocrine-related Cancer·Emma H Allott, Stephen D Hursting
Nov 19, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·C HopeE English
Jan 1, 2016·Cell Death & Disease·Y Poloz, V Stambolic
Jan 5, 2016·The Journal of Clinical Investigation·Varman T Samuel, Gerald I Shulman
Jan 24, 2016·Journal of Translational Medicine·Javier Martinez-Useros, Jesus Garcia-Foncillas
Feb 24, 2016·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·UNKNOWN Canadian Task Force on Preventive Health Care
Apr 20, 2016·Diabetologia·Hannele Yki-Järvinen

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Citations

Dec 24, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C-C ChinJ-M Chiang
Mar 10, 2020·International Journal of Cancer. Journal International Du Cancer·Chun-Han LoMingyang Song
Apr 8, 2020·BioMed Research International·Gitana Maria AcetoMaria Cristina Curia
Jun 4, 2020·Cellular Oncology (Dordrecht)·Łukasz ZadkaPiotr Dzięgiel
Jul 10, 2019·Gastroenterology Research and Practice·Lijuan HuangLizheng Fang
Jul 3, 2021·Clinics and Research in Hepatology and Gastroenterology·Huadong WuBaojun Zhou

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