Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone

The Journal of Comparative Neurology
Yumiko HatanakaFujio Murakami

Abstract

Time-lapse studies indicate that ventricular zone (VZ)-derived cells show two migratory modes in the cerebral cortex at different stages of mammalian embryogenesis: somal translocation and locomotion. We carried out a systematic analysis to examine whether the migratory behavior of cortical neurons derived from the cortical VZ is stage-dependent. We labeled VZ cells of mouse embryos with green fluorescent protein (gfp) -encoding plasmids by in utero electroporation and evaluated the labeled cells after appropriate survival periods. After electroporation at either embryonic day (E) 12.5 or E15.5, GFP+ VZ cells were initially spindle-shaped and radially oriented. After leaving the VZ, they transformed into round or horizontally oriented fusiform neurons with many short processes. They then seemed to gradually change into radially oriented bipolar cells as they moved upward. Whereas the earliest emigrants from the VZ labeled at E12.5 (early-born neurons) reached the top of the cortical plate (CP) after these changes, VZ cells labeled at E15.5 (late-born neurons) further migrated along the length of radial fibers to reach the top of the CP. A dominant negative form of the gene for cyclin-dependent kinase 5 (Cdk5DN) was then introdu...Continue Reading

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Citations

Jul 19, 2012·Nature Communications·Marco dal MaschioLaura Cancedda
Apr 17, 2007·Nature Neuroscience·Leopoldo PetreanuKarel Svoboda
May 16, 2009·Nature Protocols·Benjamin JudkewitzMichael Häusser
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Jul 22, 2014·Nature·Mingshan XueMassimo Scanziani
Oct 7, 2014·Molecular and Cellular Neurosciences·Julie Renaud, Alain Chédotal
Mar 20, 2014·Development·Fernando García-MorenoZoltán Molnár
Oct 12, 2012·Cellular and Molecular Life Sciences : CMLS·Zhihua Gao, Roseline Godbout
Sep 22, 2012·Molecular and Cellular Neurosciences·Hiroki Umeshima, Mineko Kengaku
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Jul 12, 2013·Developmental Neurobiology·Patricia GuijarroXiaobing Yuan
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Dec 3, 2014·Frontiers in Cellular Neuroscience·Jonathan A Cooper
Nov 21, 2015·The Journal of Comparative Neurology·Alexander I SonMasaaki Torii

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