Distinct modulation of chemokine expression patterns in human monocyte-derived dendritic cells by prostaglandin E(2)

Cellular Immunology
Markus BrucknerDaniel F Legler

Abstract

Dendritic cells (DCs) are key in regulating immune responses. DCs reside in tissues facing the environment and sample their surrounding for pathogens. Upon pathogen encounter, DCs mature and migrate into secondary lymphoid organs. Distinct maturation signals dictate the ability of DCs to produce distinct patterns of chemokines that orchestrate immunity. Prostaglandin E(2) (PGE(2)) is produced during inflammation and modulates DC functions. We demonstrate that PGE(2) modulates distinct chemokine expression patterns of human monocyte-derived (Mo) DCs upon maturation with various stimuli. PGE(2) dampened early production of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of the T cell attractant CXCL10. In contrast, PGE(2) enhanced CXCL8 production early during maturation, whereas CXCL16 levels were continuously elevated, contributing to innate immune cell recruitment. Moreover, PGE(2) induces transcription of the homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing chemokine CCL19 and its expression was down-regulated by PGE(2).

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Citations

Dec 24, 2015·Journal of Translational Medicine·Chiara MassaBarbara Seliger
Apr 19, 2018·Journal of Leukocyte Biology·Julia M Laufer, Daniel F Legler
Feb 5, 2019·International Immunology·Tetsuya Honda, Kenji Kabashima
Apr 21, 2016·American Journal of Physiology. Endocrinology and Metabolism·Julia ManowskyGerhard P Püschel
Apr 14, 2015·Experimental Dermatology·Anja SaalbachJan C Simon
Apr 14, 2018·The Journal of Cell Biology·Markus BrownDontscho Kerjaschki
May 1, 2021·International Journal of Molecular Sciences·Marc ArtingerDaniel F Legler

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