Distinct molecular pathways in ovarian endometrioid adenocarcinoma with concurrent endometriosis

International Journal of Cancer. Journal International Du Cancer
Chi ZhangShannon M Hawkins

Abstract

Women with endometriosis, a benign growth of endometrial tissue outside the uterine cavity, are at increased risk of specific histotypes of epithelial ovarian cancer, such as ovarian endometrioid adenocarcinoma (OEA). Women with OEA who have endometriosis at time of surgical staging demonstrate improved clinical prognosis compared to women with OEA without evidence of endometriosis. However, the molecular contributions of the endometriotic tumor microenvironment to these ovarian cancers remain poorly understood. As a starting point, we used a platform for genome-wide transcriptomic profiling to compare specimens of OEA from women with and without concurrent endometriosis and benign reproductive tract tissues, including proliferative endometrium and typical and atypical endometrioma samples (n = 20). Principle component analysis revealed distinct clustering between benign and malignant samples as well as malignant samples with and without concurrent endometriosis. Examination of gene signatures revealed that OEA with concurrent endometriosis contained a unique molecular signature compared to OEA without concurrent endometriosis, distinguished by 682 unique genes differentially expressed (fold change < or >1.5, p < 0.01). Bioinfo...Continue Reading

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Citations

Apr 25, 2019·International Journal of Molecular Sciences·Konstantinos SapalidisIsaak Kesisoglou
Aug 9, 2018·Cancers·Jillian R Hufgard WendelShannon M Hawkins

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