Distinct molecular signatures in pediatric infratentorial glioblastomas defined by aCGH

Experimental and Molecular Pathology
S SharmaJohn K Cowell

Abstract

Glioblastomas (GBM) are rare in children, but reportedly have more varied outcome which suggests differences in tumor etiology compared to typical GBM of adults. To investigate this we performed high resolution array comparative genomic hybridization (aCGH) analysis on three pediatric infratentorial GBM, ages 3.5, 7 and 14 years. Two of these tumors occurred in the brainstem and one in the spinal cord. While histologically typical, one brainstem tumor showed mainly pleomorphic astrocytic cells, whereas the other brainstem and spinal tumors showed a GFAP positive small cell component. Whole chromosomal gains (#1 and #2) and loss (#20) were seen only in the pleomorphic brainstem GBM, which also showed a high level of segmental genomic copy number changes. Segmental loss involving chromosome 8 was seen in all three tumors (Chr8;133039446-136869494, Chr8;pter-3581577, and Chr8;pter-30480019 respectively), whereas loss involving chromosome 16 was seen in only 2 cases with small cell components (Chr16;31827239-qter and Chr16;pter-29754532). Segmental gain of chromosome 7 was shared only between the 2 brainstem cases (Chr7;17187166-qter and Chr7;69824947-qter). Chromosome 17 showed segmental gain of 17q in the backdrop of loss of 17p ...Continue Reading

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Citations

Apr 11, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Pilar Eguía-AguilarFrancisco Arenas-Huertero
Dec 14, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jessica Amlin-Van SchaickKarlyne M Reilly
Jan 13, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Vijay YanamadalaJohn H Shin
Nov 5, 2016·Journal of Neurosurgery. Pediatrics·Subhas K KonarAnil Nanda
Mar 27, 2013·Nature Reviews. Neurology·Patricia L ZadnikChetan Bettegowda
Feb 7, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chiagozie OnoniwuGeorge Jallo
May 10, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sun-ju ByeonSung-Hye Park
Jan 10, 2021·International Journal of Molecular Sciences·Griselda A Cabral-PachecoMargarita L Martinez-Fierro

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