Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish

ELife
Almary GuerraSven Reischauer

Abstract

The ultimate formation of a four-chambered heart allowing the separation of the pulmonary and systemic circuits was key for the evolutionary success of tetrapods. Complex processes of cell diversification and tissue morphogenesis allow the left and right cardiac compartments to become distinct but remain poorly understood. Here, we describe an unexpected laterality in the single zebrafish atrium analogous to that of the two atria in amniotes, including mammals. This laterality appears to derive from an embryonic antero-posterior asymmetry revealed by the expression of the transcription factor gene meis2b. In adult zebrafish hearts, meis2b expression is restricted to the left side of the atrium where it controls the expression of pitx2c, a regulator of left atrial identity in mammals. Altogether, our studies suggest that the multi-chambered atrium in amniotes arose from a molecular blueprint present before the evolutionary emergence of cardiac septation and provide insights into the establishment of atrial asymmetry.

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Citations

Aug 1, 2018·Development·Veronica UribeDidier Y R Stainier
Nov 24, 2018·Development·Audrey DesgrangeSigolène M Meilhac
Dec 15, 2018·Development, Growth & Differentiation·Wataru KatanoKazuko Koshiba-Takeuchi
Dec 24, 2019·ELife·Ryuichi FukudaDidier Yr Stainier
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Kendall E Martin, Joshua S Waxman
Nov 20, 2020·Nature·Rashmi PriyaDidier Y R Stainier
Feb 13, 2021·Journal of Cardiovascular Development and Disease·Yao YaoDeborah Yelon
Feb 14, 2021·Journal of Cardiovascular Development and Disease·Cassie L KemmlerChristian Mosimann
Apr 16, 2021·Developmental Biology·Ayele Taddese TsedekeRubén Marín-Juez
May 1, 2021·Journal of Cardiovascular Development and Disease·Catherine PfefferliAnna Jaźwińska
Jul 3, 2021·Journal of Cardiovascular Development and Disease·Kelly A Smith, Veronica Uribe
Aug 17, 2021·Development·Hessel HonkoopJeroen Bakkers

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Methods Mentioned

BETA
transgenic
dissection
RNAseq
PCR
ChIP-seq
confocal microscopy
affinity purification
immunoprecipitation
ChIP
transfection

Software Mentioned

Ensembl
IMARIS
FastQC
DESeq2
MOgene
featureCounts
Zen Microscope
Trimmomatic
PowerLab
TALEN Targeter

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