Distinct neural firing mechanisms to tonal stimuli offset in the inferior colliculus of mice in vivo

Neuroscience Research
Masatoshi KasaiHarunori Ohmori

Abstract

Offset neurons, which fire at the termination of sound, likely encode sound duration and serve to process temporal information. Offset neurons are found in most ascending auditory nuclei; however, the neural mechanisms that evoke offset responses are not well understood. In this study, we examined offset neural responses to tonal stimuli in the inferior colliculus (IC) in vivo with extracellular and intracellular recording techniques in mice. Based on peristimulus time histogram (PSTH) patterns, we classified extracellular offset responses into four types: Offset, Onset-Offset, Onset-Sustained-Offset and Inhibition-Offset types. Moreover, using in vivo whole-cell recording techniques, we found that offset responses were generated in most cells through the excitatory and inhibitory synaptic inputs. However, in a small number of cells, the offset responses were generated as a rebound to hyperpolarization during tonal stimulation. Many offset neurons fired robustly at a preferred duration of tonal stimulus, which corresponded with the timing of rich excitatory synaptic inputs. We concluded that most IC offset neurons encode the termination of the tone stimulus by responding to inherited ascending synaptic information, which is tun...Continue Reading

References

May 19, 1978·Science·E I Knudsen, M Konishi
Jan 1, 1992·Experimental Brain Research·J M ToronchukM S Cynader
Jan 1, 1991·The Journal of Comparative Neurology·D L OliverC K Henkel
Apr 1, 1986·Neuroscience·V MeiningerP Derer
Mar 1, 1972·The Journal of Comparative Neurology·K K Osen
May 20, 1981·The Journal of Comparative Neurology·E S KaneB S Gordon
Nov 9, 2000·Neuroscience Research·N TamamakiT Kaneko
Sep 8, 2001·Journal of the Association for Research in Otolaryngology : JARO·R J Kulesza, A S Berrebi
Jul 24, 2002·Pflügers Archiv : European journal of physiology·Troy W MargrieBert Sakmann
Aug 31, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruili XieGeorge D Pollak
Apr 17, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Kouichi C NakamuraTakeshi Kaneko
May 20, 2009·Hearing Research·Rapeechai Navawongse, Herbert F Voigt
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Brandon AubiePaul A Faure
Dec 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ling QinYu Sato
Feb 10, 2011·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Riziq SayeghPaul A Faure
Sep 2, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard A FelixAnna K Magnusson
Sep 10, 2011·Neuron·Cornelia Kopp-ScheinpflugIan D Forsythe

❮ Previous
Next ❯

Citations

Sep 13, 2015·The Journal of Physiological Sciences : JPS·Munenori Ono, Tetsufumi Ito
Jun 22, 2015·The Journal of the Acoustical Society of America·Samira AndersonNina Kraus
Oct 28, 2014·Frontiers in Neurology·Joel I BergerAlan R Palmer
Oct 1, 2016·Scientific Reports·Hironori BabaKatsuei Shibuki
Mar 25, 2021·ELife·Giulio BondanelliSrdjan Ostojic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.