Distinct neural mechanisms underlying acute and repeated administration of antipsychotic drugs in rat avoidance conditioning.

Psychopharmacology
M LiGang Hu

Abstract

Acute antipsychotic treatment disrupts conditioned avoidance responding, and repeated treatment induces a sensitization- or tolerance-like effect. However, the neurochemical mechanisms underlying both acute and repeated antipsychotic effects remain to be determined. The present study examined the neuroreceptor mechanisms of haloperidol, clozapine, and olanzapine effect in a rat two-way conditioned avoidance model. Well-trained Sprague-Dawley rats were administered with haloperidol (0.05 mg/kg, sc), clozapine (10.0 mg/kg, sc), or olanzapine (1.0 mg/kg, sc) together with either saline, quinpirole (a selective dopamine D(2/3) agonist, 1.0 mg/kg, sc), or 2,5-dimethoxy-4-iodo-amphetamine (DOI; a selective 5-HT(2A/2C) agonist, 2.5 mg/kg, sc), and their conditioned avoidance responses were tested over 3 days. After 2 days of drug-free retraining, the repeated treatment effect was assessed in a challenge test. Pretreatment of quinpirole, but not DOI, attenuated the acute haloperidol-induced disruption of avoidance responding and to a lesser extent, olanzapine-induced disruption. In contrast, pretreatment of DOI, but not quinpirole, attenuated the acute effect of clozapine. On the repeated effect, pretreatment of DOI, but not quinpirole...Continue Reading

References

Apr 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S B CaineN R Swerdlow
Dec 27, 1995·European Journal of Pharmacology·M L Wadenberg, S Ahlenius
Nov 1, 1996·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·M L WadenbergS Ahlenius
Aug 1, 1997·Brain Research. Molecular Brain Research·P R BucklandP McGuffin
Apr 26, 2000·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·S KapurG Remington
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M L WadenbergS Kapur
May 7, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Eli O Meltzer
Sep 13, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stefania BonaccorsoJunji Ichikawa
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shitij KapurJose N Nobrega
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Herbert Y MeltzerJunji Ichikawa
Jun 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ming LiShitij Kapur
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Faïza BenaliouadPierre-Paul Rompré
Jan 16, 2007·Behavioural Pharmacology·Andrew J GoudieHarry R Sumnall
Mar 3, 2007·Journal of Psychopharmacology·Andrew J GoudieHarry R Sumnall
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John M DavisIra D Glick
Jun 24, 2008·Pharmacology, Biochemistry, and Behavior·Mike F HawkinsAlan A Baumeister
Dec 25, 2008·Psychopharmacology·Steven M GrauerSharon Rosenzweig-Lipson
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adam L HalberstadtSusan B Powell

❮ Previous
Next ❯

Citations

Nov 8, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jing QiaoMing Li
Nov 21, 2015·European Journal of Pharmacology·Jun GaoMing Li
Oct 22, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jing QiaoMing Li
Apr 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Changjiu ZhaoMing Li
Aug 6, 2013·Behavioural Processes·Ming Li, Wei He
Apr 17, 2017·Behavioural Brain Research·Xiaojing DingMing Li
Mar 30, 2017·Journal of Psychopharmacology·Min FengMing Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here