Distinct neural representations of placebo and nocebo effects

NeuroImage
Sonya FreemanJian Kong

Abstract

Expectations shape the way we experience the world. In this study, we used fMRI to investigate how positive and negative expectation can change pain experiences in the same cohort of subjects. We first manipulated subjects' treatment expectation of the effectiveness of three inert creams, with one cream labeled "Lidocaine" (positive expectancy), one labeled "Capsaicin" (negative expectancy) and one labeled "Neutral" by surreptitiously decreasing, increasing, or not changing respectively, the intensity of the noxious stimuli administered following cream application. We then used fMRI to investigate the signal changes associated with administration of identical pain stimuli before and after the treatment and control creams. Twenty-four healthy adults completed the study. Results showed that expectancy significantly modulated subjective pain ratings. After controlling for changes in the neutral condition, the subjective pain rating changes evoked by positive and negative expectancies were significantly associated. fMRI results showed that the expectation of an increase in pain induced significant fMRI signal changes in the insula, orbitofrontal cortex, and periaqueductal gray, whereas the expectation of pain relief evoked signific...Continue Reading

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Citations

Jan 13, 2017·PLoS Computational Biology·Abby TaborKonrad P Körding
Apr 8, 2016·Cephalalgia : an International Journal of Headache·Zhengjie LiJian Kong
Feb 9, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A IcenhourS Elsenbruch
Dec 23, 2016·Social Cognitive and Affective Neuroscience·Philipp ReichertsMatthias J Wieser
Oct 27, 2017·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Daniel PachClaudia M Witt
Aug 18, 2018·Expert Review of Clinical Immunology·Lieven PouillonLaurent Peyrin-Biroulet
Aug 9, 2019·American Journal of Physical Medicine & Rehabilitation·Ginger PolichRoss Zafonte
Dec 6, 2019·Zeitschrift für Rheumatologie·J BraunU Kiltz
Aug 11, 2020·Korean journal of anesthesiology·Felipe Muñoz-LeyvaKi Jinn Chin
Feb 18, 2017·Brain Imaging and Behavior·Anne SchienleAlbert Wabnegger
Oct 4, 2017·Pain Reports·Maxie BlasiniLuana Colloca
Mar 28, 2019·Frontiers in Pharmacology·Nina ZechErnil Hansen
Oct 27, 2018·Nature Reviews. Rheumatology·Evrydiki KravvaritiPetros P Sfikakis
Nov 17, 2020·Frontiers in Psychology·Martina AmanzioJian Kong
Dec 29, 2020·Medical Acupuncture·Jian Kong, Maya Nicole Eshel
Mar 4, 2021·Nature Communications·Matthias ZunhammerUNKNOWN Placebo Imaging Consortium
May 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yiheng TuJian Kong
May 9, 2021·Scientific Reports·Mia A ThomaidouAndrea W M Evers
Jun 20, 2021·Scandinavian Journal of Psychology·Áron HorváthAttila Szabo
Jun 9, 2021·European Journal of Pain : EJP·Shervin VencatachellumClaus Vögele

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