Distinct parasegmental and imaginal enhancers and the establishment of the expression pattern of the Ubx gene.

Genetics
Vincenzo PirrottaS Qian

Abstract

The expression domain of the Ubx gene in Drosophila embryos is bounded by the product of the hb gene, acting as a repressor. We show that all Ubx fragments that bind Hb protein in vitro contain parasegmental enhancers active in the embryo in specific parasegmental patterns. We have found three new embryonic enhancer elements in the upstream region, in addition to the two previously identified. Each produces a pattern initially bounded at PS6 by Hb but sooner or later breaks down this boundary and begins to express in the anterior region. These enhancers do not respond to the long-term maintenance mediated by the Polycomb group of genes. They also cease functioning after germ band extension. Expression in imaginal tissues is due to a set of entirely separate and independent imaginal disc enhancers. These do not contain Hb binding sites and by themselves have no anterior/posterior positional information, although some distinguish between ventral and dorsal discs. A third kind of element, the Polycomb Response Element (PRE), has no enhancer activity but causes long-term maintenance of the expression domain of other enhancers present in the vicinity. The interaction of these elements results in the correct expression of Ubx in imag...Continue Reading

Citations

Mar 25, 2006·Development·Robert K Maeda, François Karch
Jan 18, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Adelheid Lempradl, Leonie Ringrose
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·Y B SchwartzV Pirrotta
Dec 1, 2004·Annual Review of Genetics·Leonie Ringrose, Renato Paro
Jul 5, 2006·Development·Jozsef MihalyFrançois Karch
Nov 14, 2002·Annual Review of Genetics·Ian W Duncan
Jul 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·László SiposWelcome Bender
Nov 8, 2020·Genetics·Welcome W Bender
Oct 16, 2021·Genome Research·Zarmik MoqtaderiWelcome Bender
Jan 5, 2011·PLoS Genetics·Carole IampietroRobert K Maeda
Jan 19, 2011·Cell·Frédéric BantigniesGiacomo Cavalli

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