Distinct pattern of oculomotor impairment associated with acute sleep loss and circadian misalignment

The Journal of Physiology
Leland S StoneErin E Flynn-Evans

Abstract

Inadequate sleep and irregular work schedules have not only adverse consequences for individual health and well-being, but also enormous economic and safety implications for society as a whole. This study demonstrates that visual motion processing and coordinated eye movements are significantly impaired when performed after sleep loss and during the biological night, and thus may be contributing to human error and accidents. Because affected individuals are often unaware of their sensorimotor and cognitive deficits, there is a critical need for non-invasive, objective indicators of mild, yet potentially unsafe, impairment due to disrupted sleep or biological rhythms. Our findings show that a set of eye-movement measures can be used to provide sensitive and reliable indicators of such mild neural impairments. Sleep loss and circadian misalignment have long been known to impair human cognitive and motor performance with significant societal and health consequences. It is well known that human reaction time to a visual cue is impaired following sleep loss and circadian misalignment, but it has remained unclear how more complex visuomotor control behaviour is altered under these conditions. In this study, we measured 14 parameters ...Continue Reading

References

Jan 1, 1976·Vision Research·M J Steinbach
Dec 1, 1975·Biological Psychology·J A Horne
Aug 1, 1992·Vision Research·L S Stone, P Thompson
May 1, 1990·Journal of Experimental Psychology. Human Perception and Performance·R K MorrisA Pollatsek
Aug 1, 1990·Visual Neuroscience·R S GellmanF A Miles
Feb 1, 1988·Sleep·M M MitlerR C Graeber
Oct 1, 1987·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·J Santamaria, K H Chiappa
May 1, 1988·Annals of Clinical Biochemistry·M E Aldhous, J Arendt
Jan 1, 1987·Vision Research·B Khurana, E Kowler
Jan 1, 1987·Annual Review of Neuroscience·S G LisbergerL Tychsen
Oct 1, 1986·Journal of Neurophysiology·L Tychsen, S G Lisberger
Jan 1, 1986·Biological cybernetics·D A RobinsonS E Gordon
Oct 1, 1971·Vision Research·S Heywood, J Churcher
Oct 1, 1965·The Journal of Physiology·D A Robinson
Jan 1, 1984·Experimental Brain Research·V HennK Hepp
Jan 1, 1981·Annual Review of Neuroscience·D A Robinson
Apr 1, 1995·Annals of Neurology·M J Morrow, J A Sharpe
Oct 21, 1993·Behavioural Brain Research·U J IlgK P Hoffmann
Jan 1, 1993·Vision Research·M J Morrow, J A Sharpe
Jan 1, 1996·Optometry and Vision Science : Official Publication of the American Academy of Optometry·M Bach
Oct 1, 1996·Brain : a Journal of Neurology·J J BartonJ E Raymond
Dec 1, 1996·Brain : a Journal of Neurology·W HeideD Kömpf
Jun 1, 1997·Experimental Brain Research·F ButzerJ M Zanker
Jul 1, 1997·Vision Research·C von Hofsten, K Rosander
Nov 19, 1997·Progress in Neurobiology·U J Ilg
Apr 22, 1999·Vision Research·S N Watamaniuk, S J Heinen
Jul 13, 1999·Journal of Neurophysiology·L Petit, J V Haxby
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L De GennaroM Bertini
Nov 7, 2000·Perception·L S StoneJ Lorenceau
Aug 11, 2001·Visual Neuroscience·R J Krauzlis, S A Adler
Feb 12, 2002·Journal of Biological Rhythms·Jeanne F Duffy, Derk-Jan Dijk
Mar 6, 2002·Journal of Neurophysiology·Sophie de BrouwerPhilippe Lefèvre
Apr 4, 2002·Journal of Neurophysiology·Sophie de BrouwerPhilippe Lefèvre
Oct 31, 2002·Human Psychopharmacology·N. QuigleyD. J. King

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Citations

Feb 29, 2020·The Journal of Physiology·Mohannad GhanemTharmegan Tharmaratnam
Sep 13, 2020·Nature Communications·Nachiappan ValliappanVidhya Navalpakkam
Mar 13, 2021·NPJ Digital Medicine·Vincent Wen-Sheng TsengVidhya Navalpakkam
May 21, 2021·Nursing·Jennifer N Kain, Tara J Sharpp

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